Results 121 to 130 of about 1,610 (139)

Proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia susceptibility: a meta-analysis

Metabolic Brain Disease, 2017
Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk.
Xingzhi, Guo, Peng, Tang, Caiping, Yang, Rui, Li   +3 more
openaire   +2 more sources

Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation

Psychiatric Genetics, 2008
Type I hyperprolinemia (HPI) is an autosomal recessive disorder caused by proline oxidase deficiency. This enzyme is encoded by the proline dehydrogenase (PRODH) gene on 22q11. The functional consequences of different PRODH mutations on proline oxidase activity have been characterized in vitro.
DI ROSA, GABRIELLA, PUSTORINO GIUSEPPIN, OLIVIA, SPANO M, CAMPION D, CALABRÒ M, AGUENNOUZ, M'hammed, CACCAMO, Daniela, LEGALLIC S, SGRO DL, BONSIGNORE M, TORTORELLA, Gaetano   +10 more
openaire   +3 more sources

Abstract 5402: A new anticancer strategy based on inhibiting mitochondrial proline dehydrogenase (PRODH) and exploiting synthetic lethal interactions with p53 restoration and/or glutaminase (GLS1) inhibition

Cancer Research, 2015
Abstract From prokaryotes to the highest eukaryotes, proline is catabolized by a unique and structurally conserved flavoprotein, proline dehydrogenase (PRODH). In eukaryotes PRODH associates with the inner mitochondrial membrane and catalyzes the first and rate limiting catabolic step, transferring two electrons to the electron transport
Gary K. Scott, Justine Rutter, Katya Frazier, Daniel Rothschild, Christina Yau, Christopher Benz   +5 more
openaire   +1 more source

Pharmacoinformatics and molecular docking studies reveal potential novel Proline Dehydrogenase (PRODH) compounds for Schizophrenia inhibition

Medicinal Chemistry Research, 2016
Studies on Schizophrenia, so far reveal a complex picture of neurological malfunctioning reported to be strongly associated with proline dehydrogenase (PRODH). This study employs in silico hybrid approach for virtual screening and molecular docking followed by pharmacophore identification and structural modeling.
openaire   +1 more source

Analysis of the Proline Dehydrogenase/Proline Oxidase importance in NSAIDs-induced apoptosis by using the CRISPR/Cas9 PRODH/POX-knockout MCF7 breast cancer model

Book of Abstracts, 2022
Arkadiusz Surażyński, Adam Kazberuk, Magda Chalecka, Jerzy Pałka   +3 more
openaire   +1 more source

Proline dehydrogenase 1 (PRODH; POX)

Science-Business eXchange, 2012
openaire   +1 more source

Proline Dehydrogenase in Cancer: Apoptosis, Autophagy, Nutrient Dependency and Cancer Therapy

Amino Acids, 2021
Chao Mao, Ying Shi, Desheng Xiao
exaly  

Functional analysis of bZIP transcription factors involved in hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis

Plant and Cell Physiology Supplement, 2005
Satoh, Rie, Fujita, Yasunari, Nakashima, Kazuo, Shinozaki, Kazuo, Yamaguchi-Shinozaki, Kazuko   +4 more
openaire   +1 more source

Schizophrenia-Like Behaviors Arising From Dysregulated Proline Metabolism Are Associated With Altered Neuronal Morphology and Function in Mice With Hippocampal PRODH Deficiency

Aging and disease, 2023
Yuxiao Yao, Weiping Han, Huanxing Su
exaly  

Biochemical Characterization of Proline Dehydrogenase in Arabidopsis Mitochondria

FEBS Journal, 2014
Cecile Cabassa, Hans-Peter Braun, Arnould Savouré   +2 more
exaly