Results 21 to 30 of about 46,423 (228)
Sources of superoxide/H2O2 during mitochondrial proline oxidation
Redox Biology, 2014 p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves +5 more
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Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]
PLoS ONE, 2013 Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao +6 more
doaj +1 more source
Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
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Microbial Cell, 2016 The amino acid proline functions as a nitrogen source and as a stress protectant in the yeast Saccharomyces cerevisiae. However, utilization of proline as a carbon source in S. cerevisiae cells has not been studied yet.
Ikuhisa Nishida +2 more
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Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. [PDF]
Amino Acids, 2016 Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship between PRODH/POX and regulation of ...
Hancock CN, Liu W, Alvord WG, Phang JM.
europepmc +4 more sources
Biologia Plantarum, 2017 Proline is emerging as a critical component of drought tolerance and fine tuning of its metabolism under stress affects the plants sensitivity and response to stress.
D. Kaur, S. K. Grewal, J. Kaur, S. Singh
doaj +1 more source
Cells, 2021 The study examines the effect of acclimation on the antioxidant system and proline metabolism in cucumber leaves subjected to 100 and 150 NaCl stress.
Marcin Naliwajski, Maria Skłodowska
doaj +1 more source
The sodium/proline transporter PutP of Helicobacter pylori. [PDF]
PLoS ONE, 2013 Helicobacter pylori is cause of chronic gastritis, duodenal ulcer and gastric carcinoma in humans. L-proline is a preferred energy source of the microaerophilic bacterium. Previous analyses revealed that HpputP and HpputA, the genes that are predicted to
Araceli Rivera-Ordaz +8 more
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Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein [PDF]
Nature Structural Biology, 2003 The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes. The human homolog of the PutA proline dehydrogenase (PRODH) domain is critical in p53-mediated apoptosis and schizophrenia.
Yong-Hwan, Lee +4 more
openaire +2 more sources
Current Plant Biology, 2023 Proline/P5C cycle between mitochondria and cytosol, play important roles in energy supply and ROS (Reactive oxygen species) generation in mammalian cell.
Wenhan Ying +6 more
doaj +1 more source