Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis [PDF]
BMC Plant Biology, 2010 Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun +2 more
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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Palka J, Oscilowska I, Szoka L.
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Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase. [PDF]
Org Biomol Chem, 2022 PRODH plays a central role in the metabolic rewiring of cancer cells. Analysis of 18 proline analogs using kinetics and crystallography revealed an unexpected synergism between inhibitor ring size and hydrogen bonding to an active site water molecule.
Bogner AN, Tanner JJ.
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Trimming proline dehydrogenase : protein and cofactor minimization
, 2017 Proline is one of the proteinogenic amino acids and one of the most abundant amino acids in the cell. Next to serving as one of the non-essential amino acids, proline also has a central role in metabolism. In Chapter 1, the different functions of this imino acid are described, as well as the proline metabolic enzymes. The focus is on the enzyme proline
Huijbers, Mieke M.E.
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Production of Recombinant Proline Dehydrogenase Enzyme from Pseudomonas fluorescens pf-5 in E. coli System [PDF]
Journal of Sciences, Islamic Republic of Iran, 2011 Proline dehydrogenase (ProDH; 1.5.99.8) belongs to superfamily of amino acid dehydrogenase, which plays a significant role in the metabolic pathway from proline to glutamate. The goal of this research was gene cloning and characterization of ProDH enzyme
E. Omidinia
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Intriguing Role of Proline in Redox Potential Conferring High Temperature Stress Tolerance
Frontiers in Plant Science, 2022 Proline is a proteinogenic amino acid synthesized from glutamate and ornithine. Pyrroline-5-carboxylate synthetase and pyrroline-5-carboxylate reductase are the two key enzymes involved in proline synthesis from glutamate.
P. B. Kavi Kishor +3 more
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Iranian Journal of Microbiology, 2011 Background and Objectives: Proline dehydrogenase (ProDH; 1.5.99.8) plays an important role in specific determination of plasma proline level in biosensor and diagnostic kits.
H Shahbaz- Mohammadi, E Omidinia
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Rapid Reaction Kinetics of Proline Dehydrogenase in the Multifunctional Proline Utilization A Protein [PDF]
Biochemistry, 2011 The multifunctional proline utilization A (PutA) flavoenzyme from Escherichia coli catalyzes the oxidation of proline to glutamate in two reaction steps using separate proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate (P5C) dehydrogenase domains.
Michael A, Moxley, Donald F, Becker
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Altered Levels of Proline Dehydrogenase Cause Hypersensitivity to Proline and Its Analogs in Arabidopsis [PDF]
Plant Physiology, 2002 Abstract Pro dehydrogenase (PDH) catalyzes the first and rate-limiting step in the Pro catabolic pathway. In Arabidopsis, this enzyme is encoded byAt-PDH. To investigate the role of Pro catabolism in plants, we generated transgenic Arabidopsis plants with altered levels of PDH by sense (PDH-S plants) and antisense (PDH-AS plants ...
Mani, Srikrishnan +3 more
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The Proline Dehydrogenase Gene CsProDH1 Regulates Homeostasis of the Pro-P5C Cycle Under Drought Stress in Tea Plants. [PDF]
Int J Mol SciThe homeostasis of the proline-Δ1-pyrroline-5-carboxylate (Pro-P5C) cycle, mediated by proline dehydrogenase (ProDH), plays a critical role in plants in response to abiotic stresses. The biological function of gene CsProDH1 under drought stress and
Deng D +7 more
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