Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase. [PDF]
Org Biomol Chem, 2022 PRODH plays a central role in the metabolic rewiring of cancer cells. Analysis of 18 proline analogs using kinetics and crystallography revealed an unexpected synergism between inhibitor ring size and hydrogen bonding to an active site water molecule.
Bogner AN, Tanner JJ.
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Iranian Journal of Microbiology, 2011 Background and Objectives: Proline dehydrogenase (ProDH; 1.5.99.8) plays an important role in specific determination of plasma proline level in biosensor and diagnostic kits.
H Shahbaz- Mohammadi, E Omidinia
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Proline-Aromatic Sequences Stabilize Turns via C–H/π interactions in both cis-Proline and trans-Proline [PDF]
, 2023 In proteins, proline-aromatic sequences exhibit increased frequencies of cis-proline amide bonds, via proposed C–H/π interactions between the aromatic ring and either the proline ring or the backbone C–Hα of the residue prior to proline.
Michael B., Elbaum +2 more
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Rapid Reaction Kinetics of Proline Dehydrogenase in the Multifunctional Proline Utilization A Protein [PDF]
Biochemistry, 2011 The multifunctional proline utilization A (PutA) flavoenzyme from Escherichia coli catalyzes the oxidation of proline to glutamate in two reaction steps using separate proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate (P5C) dehydrogenase domains.
Michael A, Moxley, Donald F, Becker
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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate. [PDF]
ACS Chem Biol, 2020 Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of interest.
Campbell AC +3 more
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Altered Levels of Proline Dehydrogenase Cause Hypersensitivity to Proline and Its Analogs in Arabidopsis [PDF]
Plant Physiology, 2002 Abstract Pro dehydrogenase (PDH) catalyzes the first and rate-limiting step in the Pro catabolic pathway. In Arabidopsis, this enzyme is encoded byAt-PDH. To investigate the role of Pro catabolism in plants, we generated transgenic Arabidopsis plants with altered levels of PDH by sense (PDH-S plants) and antisense (PDH-AS plants ...
Mani, Srikrishnan +3 more
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Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. [PDF]
Amino Acids, 2016 Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship between PRODH/POX and regulation of ...
Hancock CN, Liu W, Alvord WG, Phang JM.
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Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]
PLoS ONE, 2013 Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao +6 more
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Formulation, Characterisation and Evaluation of the Antihypertensive Peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline in Chitosan Nanoparticles Coated with Zein for Oral Drug Delivery [PDF]
, 2023 Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat models.
Danish, Minna K. +4 more
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Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
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