Proline-specific aminopeptidase P prevents replication-associated genome instability. [PDF]
, 2022 Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular ...
Consuelo Barroso (411488) +9 more
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Proline-Mediated Transition Metal-Free Access to 1H‑Indazolones from 2‑Halobenzohydrazides [PDF]
, 2016 Transition metal-free access to 1H-indazolones 1 has been achieved on the basis of base-mediated intramolecular C–N bond formation. Reactions of 2-halobenzohydrazides 2 with potassium tert-butoxide in the presence of catalytic proline provided ...
Miho Tsujii (2879000) +2 more
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New Binaphthyl-Proline-Based Chiral Ligands Bearing Imidazoline Groups: Design, Synthesis, and Their Application in Enantioselective Conjugate Addition of 4‑Hydroxycoumarin and Related Nucleophiles to β,γ-Unsaturated α‑Ketoesters [PDF]
, 2023 This paper describes the design and application of new binaphthyl-proline-based chiral ligands bearing imidazoline functional groups. These chiral ligands incorporate the advantages of both the binaphthyl and proline skeletons, they are featured with ...
Jiahui Li (646449) +5 more
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Фактори експериментальної еволюції організмів, 2017 Aim. The investigation of the T3 transgenic sunflower plants osmotic tolerance there were developed. The levels of free proline in plant shoots and roots were estimated. Methods. Mature sunflower plants (T3 and wild type) were cultured in standard pots.
A. G. Komisarenko, S. I. Mykhalska
doaj +1 more source
Direct l-Proline-Catalyzed Asymmetric α-Amination of Ketones [PDF]
, 2016 The first direct catalytic asymmetric α-amination of ketones catalyzed by l-proline has been developed. The reactions proceed with various azodicarboxylates as the nitrogen source in high yields and excellent enantioselectivities (up to 99% ee).
Wei Zhuang (146641) +4 more
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Stomatitis Healing via Hydrogels Comprising Proline, Carboxyvinyl Polymer, and Water
GelsChemotherapy using anticancer agents and radiotherapy of cancers frequently induce the development of stomatitis as a side effect. In the present study, hydrogels for effective stomatitis healing under anticancer drug administration were developed using ...
Raichi Hanaki +4 more
doaj +1 more source
Frontiers in Plant Science, 2015 Proline accumulation is a common response to salt stress in many plants. Salt stress also increased proline concentration in roots, stems and leaves of Kosteletzkya virginica seedling treated with 300mM NaCl for 24h and reached 3.75, 4.76 and 6.83 fold ...
Hongyan eWang +7 more
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Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase [PDF]
, 2013 Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle.
Bastie, Claire C. +6 more
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Auxotrophy from bioenergetic demand: the case of proline addiction in Clostridioides difficile
mSphereMany microbial growth requirements are interpreted as auxotrophy arising from loss of biosynthetic capacity. Clostridioides difficile is widely considered to be proline auxotrophic because it fails to grow in defined media lacking proline, yet it harbors
Michael A. Johnstone, William T. Self
doaj +1 more source
Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress [PDF]
PeerJThe aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25%
Joanna Kijowska-Oberc +3 more
doaj +2 more sources