Results 61 to 70 of about 303,245 (307)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide [PDF]
, 2016 The incorporation into a peptide chain of highly hindered and weakly nucleophilic trifluoromethylated prolines, pseudoprolines and oxazolidines has been achieved.
Julien Pytkowicz (1643020) +4 more
core +1 more source
The puckering free-energy surface of proline
AIP Advances, 2013 Proline has two preferred puckering states, which are often characterized by the pseudorotation phase angle and amplitude. Although proline's five endocyclic torsion angles can be utilized to calculate the phase angle and amplitude, it is not clear if ...
Di Wu
doaj +1 more source
Relationship between calcification, atherosclerosis and matrix proteins in the human aorta
Folia Histochemica et Cytobiologica, 2021 INTRODUCTION: Extracellular matrix (ECM) proteins have been associated with atherosclerotic complications, such as plaque rupture, calcification and aneurysm.
Aleksandra Kuzan +5 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Efficient and convenient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline [PDF]
, 2016 An efficient, four-component, one-pot condensation reaction of phthalimide or phthalic anhydride, aromatic aldehydes, and ethyl cyanoacetate for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline in excellent ...
Harendra Nath Roy (2812576) +4 more
core +1 more source
Effect of exogenous proline on physiological and growth traits of melon seedlings under salt stress [PDF]
, 2023 La prolina es un aminoácido que se acumula en plantas en respuesta a condiciones de estrés. Se ha reportado que la aplicación exógena de prolina aumenta la tolerancia al estrés. Se realizó un experimento para evaluar el efecto de diferentes soluciones de
Corvalán, Belén +2 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The L-Proline-Catalyzed Asymmetric Syntheses [PDF]
, 2009 In recent years, L-proline has been employed as the catalyst for the intra-and intermolecular aldol reactions, α- amination of aldehydes and ketones, and three-component Mannich reactions.
王光昭, WANG, KUANG-CHAO
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source