Results 81 to 90 of about 303,245 (307)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana [PDF]

open access: yes, 2012
Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of ...
C. -W. Tan   +5 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Applications of ascorbic acid or proline increase resistance to salt stress in barley seedlings [PDF]

open access: yes, 2014
The present study was carried out to examine the effects of seed soaking in 1 mM ascorbic acid (AA) or 1 mM proline on the growth, content of photosynthetic pigments and proline, relative water content, electrolyte leakage, antioxidant enzymes and leaf ...
R. A. Agami
core   +1 more source

Характеристика трансгенних рослин соняшника (Helianthus annuus L.) з дволанцюговим РНК супрессором гена проліндегідрогенази

open access: yesФактори експериментальної еволюції організмів, 2016
Aim. The obtaining of osmotolerant form of sunflower (Helianthus annuus L.) by siRNA-technology. Methods. Agrobacterium-mediated transformation using LBA4404 harboring pBi2E with double-stranded RNA-suppressor, produced based on the ProDH1 gene of ...
А. Г. Комісаренко   +3 more
doaj  

DFR1-Mediated Inhibition of Proline Degradation Pathway Regulates Drought and Freezing Tolerance in Arabidopsis

open access: yesCell Reports, 2018
Summary: Proline accumulation is one of the most important adaptation mechanisms for plants to cope with environmental stresses, such as drought and freezing. However, the molecular mechanism of proline homeostasis under these stresses is largely unknown.
Yongbing Ren   +8 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

New L-proline uptake inhibitors with anti-Trypanosoma cruzi activity [PDF]

open access: yes, 2019
L-Proline is an important amino acid for the pathogenic protists belonging to Trypanosoma and Leishmania genera. In Trypanosoma cruzi, the etiological agent of Chagas disease, this amino acid is involved in fundamental biological processes such as ATP ...
Lucia, Fargnoli   +6 more
core   +1 more source

Pretreatment of Sesame Seed (Sesamum indicum L.) with Proline and its Effective on Seed Germination and Plant Physiological Defense Systems under Different Temperature Regimes [PDF]

open access: yesIkufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2016
To study the effects of proline and temperature on the rates of antioxidant enzymes and germination index, a factorial laboratory experiment based on completely randomized design was conducted with three replications at the Mohaghegh Ardabili University ...
Nasibeh Tavakoli   +3 more
doaj  

Determination of the Stress Responses and Mineral Compositions of Some Common Wheats (Triticum aestivum L.) under Salt Treatment

open access: yesYüzüncü Yıl Üniversitesi Tarim Bilimleri Dergisi, 2021
The aim of this research is to evaluate and analyze the influence of different degrees of salt stress on the tolerance of Australian wheat lines having characteristics derived from wild types in comparison with a local cultivar well–adapted to Anatolian ...
Hasan CAN   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy