Results 81 to 90 of about 321,948 (292)

Engineering Metal‐Pocket Cooperativity in Single‐Atom COF Nanozymes for Selective Cascade Catalysis

Advanced Materials, EarlyView.
A multilevel programming strategy is developed to engineer single‐atom COF nanozymes with tunable metal centers and chiral pockets inspired by heme–pocket cooperativity. This approach enables controlled metal–pocket interplay for asymmetric cascade catalysis, delivering high activity, selectivity, and recyclability in an asymmetric oxidation–aldol ...
Ziping Li, Qijun Sun, Yawen Hao, Haotian Wen, Shery Chang, Fengwang Li, Jiangtao Xu, Kang Liang   +7 more
wiley   +1 more source

Universal Gripper for Industrial Manipulation With Enhanced Rigid Mechanics and Self‐Adaptable Fingers

Advanced Robotics Research, EarlyView.
An enhanced universal gripper combining rigid mechanics with self‐adaptable fingers is presented for industrial automation. The novel six‐bar linkage with integrated compliant pad eliminates mechanical interference while enabling passive shape adaptation.
Muhammad Usman Khalid, Nirmal Kumar Ravikumar, Mattia Frascio, Sumanth Nagalakunta, Alessandro Seitone, Benoît Lévesque, Alessandro Zanella, Matteo Zoppi   +7 more
wiley   +1 more source

Functional specialization in proline biosynthesis of melanoma.

PLoS ONE, 2012
Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage.
Jessica De Ingeniis, Boris Ratnikov, Adam D Richardson, David A Scott, Pedro Aza-Blanc, Surya K De, Marat Kazanov, Maurizio Pellecchia, Ze'ev Ronai, Andrei L Osterman, Jeffrey W Smith   +10 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Influência do tempo de aclimatação na resposta do cajueiro à salinidade Influence of acclimatization time on response of cashew plant to salinity

Revista Brasileira de Engenharia Agrícola e Ambiental, 2007
A resposta das plantas à salinidade depende de fatores fisiológicos, bioquímicos e genéticos. Com este trabalho, objetivou-se estudar o impacto do tempo de aclimatação à solução nutritiva sobre a resposta do cajueiro à salinidade.
Jean C. A. Brilhante, Joaquim A. G. Silveira, Iza M. A. Rocha, Déborah L. de Morais, Ricardo A. Viégas   +4 more
doaj   +1 more source

Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide

, 2016
The incorporation into a peptide chain of highly hindered and weakly nucleophilic trifluoromethylated prolines, pseudoprolines and oxazolidines has been achieved.
Julien Pytkowicz (1643020), Grégory Chaume (1643023), Thierry Brigaud (1643014), Nathalie Lensen (1688296), Julien Simon (1896715)   +4 more
core   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Effect of Drought Stress on Proline Accumulation in Peanut Genotypes [PDF]

, 2014
The changes in the concentration of total protein, total free amino acids and free proline in the leaves of drought susceptible and drought tolerant varieties of peanut was studied under various durations of drought stress.
Sarangi, S.K., Jayant, K.Solanki.
core  

Proline-specific aminopeptidase P prevents replication-associated genome instability.

, 2022
Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular ...
Consuelo Barroso (411488), R Elwyn Isaac (12059525), Enrique Martinez-Perez (144292), Maikel Castellano-Pozo (108927), Hannah Craig (12004098), Kenichiro Matsuzaki (18979), Simon J Boulton (8274444), Nicola Silva (5349767), Monica Roman-Trufero (10729578), Darren R Brooks (12059522)   +9 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source