Auxotrophy from bioenergetic demand: the case of proline addiction in Clostridioides difficile [PDF]
mSphereMany microbial growth requirements are interpreted as auxotrophy arising from loss of biosynthetic capacity. Clostridioides difficile is widely considered to be proline auxotrophic because it fails to grow in defined media lacking proline, yet it harbors
Michael A. Johnstone, William T. Self
doaj +2 more sources
Proline: The Distribution, Frequency, Positioning, and Common Functional Roles of Proline and Polyproline Sequences in the Human Proteome [PDF]
PLoS ONE, 2013 Proline is an anomalous amino acid. Its nitrogen atom is covalently locked within a ring, thus it is the only proteinogenic amino acid with a constrained phi angle.
Alexander A Morgan
exaly +2 more sources
Continuous proline catalysis via leaching of solid proline [PDF]
Beilstein Journal of Organic Chemistry, 2011 Herein, we demonstrate that a homogeneous catalyst can be prepared continuously via reaction with a packed-bed of a catalyst precursor. Specifically, we perform continuous proline catalyzed α-aminoxylations using a packed-bed of L-proline.
Suzanne M. Opalka +2 more
doaj +3 more sources
A mechanochemical approach to access the proline–proline diketopiperazine framework [PDF]
Beilstein Journal of Organic Chemistry, 2017 Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides ...
Nicolas Pétry +9 more
doaj +3 more sources
Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline [PDF]
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
doaj +3 more sources
Proline-Aromatic Sequences Stabilize Turns via C–H/π interactions in both cis-Proline and trans-Proline [PDF]
, 2023 In proteins, proline-aromatic sequences exhibit increased frequencies of cis-proline amide bonds, via proposed C–H/π interactions between the aromatic ring and either the proline ring or the backbone C–Hα of the residue prior to proline.
Michael B., Elbaum +2 more
core +2 more sources
Formulation, Characterisation and Evaluation of the Antihypertensive Peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline in Chitosan Nanoparticles Coated with Zein for Oral Drug Delivery [PDF]
, 2023 Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat models.
Danish, Minna K. +4 more
core +1 more source
Biomolecules, 2021 L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu +7 more
doaj +1 more source
Current Plant Biology, 2023 Proline/P5C cycle between mitochondria and cytosol, play important roles in energy supply and ROS (Reactive oxygen species) generation in mammalian cell.
Wenhan Ying +6 more
doaj +1 more source
Serine-404 Phosphorylation and the R406W Modification in Tau Stabilize the cis-Proline Amide Bond, via Phosphoserine-Proline C–H/O and Proline-Aromatic C–H/π Interactions [PDF]
, 2023 Tau misfolding, oligomerization, and aggregation are central to the pathology of Alzheimer\u27s disease (AD), chronic traumatic encephalopathy (CTE), frontotemporal dementia, and other tauopathies.
Michael B., Elbaum +2 more
core +2 more sources