Results 71 to 80 of about 14,268,580 (205)
American Journal of Hematology, Volume 101, Issue 11, Page 2713-2725, November 2026.ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali +8 more
wiley +1 more source
THE VARIOUS SOURCES OF L-ASPARAGINASE
, 2020 ARTICLE INFO ABSTRACT L-asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma.
Dhanam Jayam, G, G Kannan
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L-ASPARAGINASE INDUCED HYPOFIBRINOGENEMIA: A CASE REPORT
, 2017 Anticancer therapy is always known to cause various side effects. L-asparaginase used in the treatment of adult T-cell lymphoblastic leukemia is anovel class of drug, an enzyme produced from plants as well as microorganisms except human.
Balaji Ommurugan +2 more
core +1 more source
Journal of Pharmacological Sciences, 2018 Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related ...
Shoya Shiromizu +4 more
doaj +1 more source
Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley +1 more source
Comparison of PEGylation methods for L-asparaginase.
, 2018 Comparison of PEGylation methods for L-asparaginase.
Josell Ramirez-Paz (3852553) +7 more
core +1 more source
Scientific AfricanThe therapeutic use of L-asparaginase derived from bacterial sources has been constrained by various challenges, including toxicity and repression. This has prompted the exploration of alternative sources, particularly eukaryotic microorganisms like ...
Dennis Kipngenoh Cheruiyot +2 more
doaj +1 more source
Predicting Functional Diversity Within Enzyme Families: A Practical Perspective
ChemBioChem, Volume 27, Issue 19, 14 October 2026.Integrating machine learning into enzyme discovery requires navigating the trade‐offs between data quantity and quality. This article provides a best‐practice framework for developing robust predictors, focusing on mitigating bias in biochemical datasets, implementing systematic “cold‐drug” validation strategies, and utilizing explainable artificial ...
Nika Sokolova, Kristina Haslinger
wiley +1 more source
Production of L-Asparaginase by Yemeni Filamentous Fungi
, 2023 Yemen with its diverse climatic regions represents a rich resource for bioactive compounds obtained from microorganisms. This study was designed to screen fungal isolates obtained from the Microbiology branch, Biological Sciences Department, Faculty of ...
Habib Thabet +3 more
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Biological Journal of Microorganism, 2016 Introduction: L- asparaginase is in an excessive demand in medical applications and in food treating industries, the request for this therapeutic enzyme is growing several folds every year.
Arastoo Badoei-dalfard +2 more
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