Results 71 to 80 of about 22,972 (221)

Improved survival with fludarabine‐based therapies in mixed phenotype acute leukaemia: A population‐based study using the WHO 2022 classification

British Journal of Haematology, EarlyView.
Summary Mixed phenotype acute leukaemia (MPAL) is a rare subtype of acute leukaemia possessing significant therapeutic challenges, as no standardized, evidence‐based treatment regimen has been defined. In this nationwide study, we aimed to assess the effect of an acute lymphoid leukaemia (ALL)‐like regimen; an acute myeloid leukaemia (AML)‐like regimen;
Lisa‐Maj Christensen, Mikkel Runason Simonsen, Jonas Faartoft Jensen, Daniel Tuyet Kristensen, Karen Dybkær, Kirsten Grønbæk, Tarec Christoffer El‐Galaly, Marianne Schmidt Ettrup, Hans Beier Ommen, Anne Louise Tølbøll Sørensen, Dennis Lund Hansen, Marianne Tang Severinsen   +11 more
wiley   +1 more source

A Comparative Study on Pseudomonal and Bacillus L. asparaginases

Journal of Pure and Applied Microbiology, 2019
The enzyme L-asparaginase is commonly used in treatment of acute lymphoblastic leukemia (ALL). Due to its therapeutic importance and growing demands in medical and food industry much of the research have been focused to produce this enzyme with better ...
Nuzhath Fatima, Mohd Mazhar Uddin Khan, Noha Emad, Khadija Al-Khadir, Amany Marwan, Ayesha Alvi   +5 more
doaj   +1 more source

Cerebral venous thrombosis in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma during induction chemotherapy with l-asparaginase: The GRAALL experience [PDF]

, 2015
International audienceCentral nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP).
Bonmati, Caroline, Bories, Pierre, Cacheux, Victoria, Chevallier, Patrice, Couturier, Marie-Anne, Daguindau, Etienne, Dombret, Hervé, Dorvaux, Véronique, Escoffre-Barbe, Martine, Frayfer, Jamile, Huguet, Françoise, Hunault-Berger, Mathilde, Ifrah, Norbert, Lhéritier, Véronique, Orvain, Corentin, Pignon, Jean-Michel, Reman, Oumedaly, Sanhes, Laurence, Suarez, Felipe, Tanguy-Schmidt, Aline, Thomas, Xavier   +20 more
core   +4 more sources

Postoperative Care and Management in Pediatric Hematology‐Oncology Patients

European Journal of Haematology, EarlyView.
ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley   +1 more source

STATISTICAL ANALYSIS OF GROWTH CONDITIONS OF NEWLY ISOLATE BACILLUS SP. PRODUCING L-ASPARAGINASE

International Islamic University Malaysia Engineering Journal, 2020
The concentrations of nutrient elements together with several physical parameters were screened to find out the significant factors for the production of L-asparaginase from newly isolated strain, Bacillus sp. from Sg Klah, Hot Spring, Perak.
Dzun Noraini Jimat, Intan Baizura Firda Mohamed, Azlin Suhaida Azmi, Azura Amid   +3 more
doaj   +1 more source

Produção da enzima antileugêmica L-Asparaginase II a partir da clonagem do Gene ErA de Erwinia Carotovora Supsp. Atroseptica em Escherichia Coli [PDF]

, 2009
As enzimas L-asparaginase do tipo II catalisam a hidrólise de L-asparagina a Laspartato e amônia e, em menor quantidade, a hidrólise de L-glutamina. Escherichia coli e Erwinia chrysanthemi são as principais origens das L-asparaginases II utilizadas como ...
Wink, Priscila Lamb
core  

Solid-phase enzyme modification via affinity chromatography [PDF]

, 2003
In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG ) by using ligand-immobilized affinity column systems L-asparagine- 2 Sepharose CL-4B
Aebi, Berg, Blanco, Butterfield, Fortier, Fusek, Greenwald, Inada, Jayaram, Jorge, Jouve, Kodera, Kurtzberg, Lee, Lentsch, Lowry, Martinez, Matsushima, Mumtaz, Ono, Petkov, Qian, Qian, Smith, Soares, Stelwagen, Swain, Turkova, Turkova, Turkova, Wissink, Wriston, Yoshimoto   +32 more
core   +1 more source

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Immunological responses to l-asparaginase [PDF]

Journal of Clinical Investigation, 1971
In a series of 40 patients treated with L-asparaginase for various neoplastic diseases, 6 patients had generalized anaphylactic reactions to L-asparaginase. Each of these reactors had antibodies detectable by passive hemagglutination, but precipitins were detectable in only one of this group of six patients. That patient had received two courses of the
R G, Peterson, R E, Handschumacher, M S, Mitchell   +2 more
openaire   +2 more sources

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, EarlyView.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source