Results 71 to 80 of about 10,199,072 (234)

INFLUENCE OF GLUCOSE AND L-ASPARAGINE CONCENTRATIONS ON L-ASPARAGINASE PRODUCTION BY ENDOPHYTIC FUNGI [PDF]

, 2017
In this study, five L-asparaginase–producing endophytes (ODL4, PBS1, PBL13, CCL1, MKS1) were evaluated for their L-asparaginase production when cultivated in various glucose (0, 0.5, 1, 2, 3, 4, 5 %) and L-asparagine (0, 5, 10, 20, 30, 40, 50 mM ...
Adeline Su Yien Ting, Ting, Adeline Su Yien, Yiing Yng Chow, Chow, Yiing Yng   +3 more
core   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

L-ASPARAGINASE INDUCED HYPOFIBRINOGENEMIA: A CASE REPORT

, 2017
Anticancer therapy is always known to cause various side effects. L-asparaginase used in the treatment of adult T-cell lymphoblastic leukemia is anovel class of drug, an enzyme produced from plants as well as microorganisms except human.
Balaji Ommurugan, Navin Patil, Amita Priya   +2 more
core   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 745-768, July/August 2026.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Production of extracellular l-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical

, 2014
L-asparaginase is an enzyme clinically accepted as an anti-tumor agent for the treatment of acute lymphoblastic leukemia and lymphosarcoma.
Oliveira, M. A., Mazzola, P. G., Monteiro, G., Farsky, S. H. P., Sette, L. D., Pessoa, A., Rangel Yagui, C. O., Carvalho, J. C. M., Magalhães, P. O., Farías, J. G. A., Motta, C. M. S., CONVERTI, ATTILIO   +11 more
core  

Factors determining therapeutic activity of L-asparaginase

, 2014
L-asparaginase (L-asp) is the basis of contemporary protocols used in the treatment of pediatric acute lymphoblastic leukemia and non-Hodgkin lymphomas.
Zalewska-Szewczyk, Beata; Klinika Pediatrii, Onkologii, Hematologii i Diabetologii Uniwersytetu Medycznego w Łodzi, Uniwersytecki Szpital Kliniczny nr 4 im. M. Konopnickiej, Łódź, Polska, Walenciak, Justyna   +1 more
core   +1 more source

Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

Journal of Pharmacological Sciences, 2018
Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related ...
Shoya Shiromizu, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo   +4 more
doaj   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

Isolasi Dan Karakterisasi Ekstrak Kasar L-Asparaginase Dari Bakteri Simbion Spons Dan Aplikasinya Sebagai Antimikroba

, 2017
L-asparagianse (L-aspargin amino hydrolase, E.C.3.5.1.1) adalah enzim yang mengkatalisis L-asparagin menjadi asam L-aspartat dan amonia. Penelitian ini bertujuan untuk mengetahui aktivitas enzim L-asparaginase yang berasal dari mikroba simbion spons dan ...
Natsir, Hasnah, Riska, Riska, Dali, Seniwati   +2 more
core  

Fungal endophyte diversity in the leaves of the medicinal plant Myracrodruon urundeuva in a Brazilian dry tropical forest and their capacity to produce L-asparaginase

, 2018
We studied the fungal endophyte community of the leaves of Myracrodruon urundeuva in Brazil along with their potential to produce L-asparaginase. In total, 187 endophytes were isolated.
Leticia Francisca da Silva (5789228), Karla Torres Lins de Sousa Freire, Leticia Francisca da Silva, Oliveira,Thays Gabrielle Lins de, Silva,Leticia Francisca da, Karla Torres Lins de Sousa Freire (5789222), Gianne Rizzuto Araújo-Magalhães, Jadson Diogo Pereira Bezerra, Freire,Karla Torres Lins de Sousa, Iolanda Ramalho da Silva, Gianne Rizzuto Araújo-Magalhães (5789231), Cristina Maria de Souza-Motta, Gualberto Segundo Agamez-Montalvo (5789234), Ana Patrícia Sousa Lopes de Pádua, Agamez-Montalvo,Gualberto Segundo, Thays Gabrielle Lins de Oliveira, Silva,Iolanda Ramalho da, Ana Patrícia Sousa Lopes de Pádua (5789219), Jadson Diogo Pereira Bezerra (5789240), Gualberto Segundo Agamez-Montalvo, Bezerra,Jadson Diogo Pereira, Araújo-Magalhães,Gianne Rizzuto, Pádua,Ana Patrícia Sousa Lopes de, Thays Gabrielle Lins de Oliveira (5789225), Iolanda Ramalho da Silva (5789237), Souza-Motta,Cristina Maria de, Cristina Maria de Souza-Motta (5789243)   +26 more
core   +1 more source