Results 91 to 100 of about 10,199,072 (234)

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

, 2012
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
core  

L-Asparaginase [PDF]

, 2021
L-Asparaginase (ASNase, EC 3.5.1.1) is a tetrameric aminohydrolase enzyme that catalyses the hydrolysis of the amino acid L-Asparagine into ammonia and L-aspartic acid.
Nunes, João C. F., Freire, Mara, Tavares, Ana Paula, Faria, Joaquim Luís, Cristóvão, Raquel, Santos-Ebinuma, Valéria, Silva, Cláudia   +6 more
core  

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

THE VARIOUS SOURCES OF L-ASPARAGINASE

, 2020
ARTICLE INFO ABSTRACT L-asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma.
Dhanam Jayam, G, G Kannan
core  

Guinea pig serum l-asparaginase: Purification, and immunological relationship to liver l-asparaginase and serum l-asparaginases in other mammals

, 1995
l-asparaginase, an enzyme used in the treatment of acute lymphocytic leukemia, is found in the serum of only a few mammalian groups, including the guinea pig and its close relatives in the superfamily Cavioidea. This report describes the purification and
Di Trapani G., Keough D., Zhang N., Clarke F., Beacham I.   +4 more
core   +2 more sources

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, Volume 36, Issue 48, 15 June 2026.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

Hidden Behind Ascites: An Atypical Pediatric Presentation of T‐Cell Acute Lymphoblastic Leukemia—A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT This case describes a child with T‐cell acute lymphoblastic leukemia (T‐ALL) presenting atypically with ascites and bilateral pedal edema, initially suggesting autoimmune hepatitis. The diagnosis was established only after flow cytometry of ascitic fluid.
Kainat Shaikh, Zahra Anas, Samia Rajput, Alizeh Zaib, Ayesha Saleem, Md Ariful Haque   +5 more
wiley   +1 more source

Isolation and Identification of L-asparaginase producing Erwinia strains which isolated from Potato Farms

Biological Journal of Microorganism, 2016
Introduction: L-Asparaginase can be effectively used for the treatment of lymphoblastic leukemia. The rapid growth of cancer cells are needed for L-asparagine abundant storage.
Arastoo Badoei-Dalfard, Zahra Karami, Narjes Ramezani–pour   +2 more
doaj  

PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients

Cell Death Discovery
Despite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia (aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed aLL the primary cause of cancer death in children.
Jung Kwon Lee, Xidi Wang, Jinghua Wang, Jesusa L. Rosales, Ki-Young Lee   +4 more
doaj   +1 more source