Results 91 to 100 of about 14,268,580 (205)

PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients

Cell Death Discovery
Despite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia (aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed aLL the primary cause of cancer death in children.
Jung Kwon Lee, Xidi Wang, Jinghua Wang, Jesusa L. Rosales, Ki-Young Lee   +4 more
doaj   +1 more source

Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study

Revista Brasileira de Hematologia e Hemoterapia
Background l-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-l-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity
Gabriela Galindo-Rodríguez, José C. Jaime-Pérez, Mario C. Salinas-Carmona, Sandra N. González-Díaz, Ángeles Castro-Corona, Raúl Cavazos-González, Humberto Treviño-Villarreal, Alberto C. Heredia-Salazar, David Gómez-Almaguer   +8 more
doaj   +1 more source

ISOLATION AND SCREENING OF L-ASPARAGINASE PRODUCING SPHINGOMONAS SP. FROM SOIL SAMPLE

Objectives: In recent years, L-asparaginase has gained attention due to its anticancer activity. Different types of asparaginase possess different characteristics and different applications.
PALANISWAMY, RADHA, L, VAISHNAVI, DEEPAK VMM   +2 more
core   +1 more source

Untersuchungen zur Asparagin Synthetase-Expression als Surrogatparameter für das Therapieansprechen auf L-Asparaginase und für L-Asparaginase Toxizität

, 2004
L-Asparaginase ist Bestandteil der Therapie der ALL und des NHL. Es katalysiert die Hydrolyse von L-Asparagin . Normale Körperzellen besitzen Asparagin Synthetase (ASYN), die die Synthese des L-Asparagins ermöglicht.
Stern, C. (Claudia)
core   +2 more sources

In vitro hemolysis test for testing the L-Asparaginase toxicity.

, 2014
A: negative control (without L-asparaginase); B: positive control (with double distilled water); C: 100 µg/ml; D: 50 µg/ml; E: 25 µg/ml; F: 12.5 µg/ml; G: 6.25 µg/ml of L-asparaginase.
Vinoth Rajendran (573696), Prahlad C. Ghosh (377762), Rajendra Kumar Saxena (573698), Vinod Kumar (48743), Saurabh Saran (573697), Richi V. Mahajan (573695)   +5 more
core   +1 more source

Chemosensitizing effect of apigenin on T-ALL cell therapy

Frontiers in Pharmacology
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with limited therapeutic options and frequent treatment-associated toxicities.
Nigar Huseynova, Züleyha Baran, Rovshan Khalilov, Afat Mammadova, Yusuf Baran   +4 more
doaj   +1 more source

Recent progress on the development of nanoparticulate L-asparaginase for enhanced anti-cancer activity

Cancer Nanotechnology
Background L-Asparaginase is a medically important enzyme known to be a chemotherapeutic agent and is often used in multi-agent chemotherapeutic regimens.
Sahand Mazloum-Ravasan, Hamed Hamishehkar   +1 more
doaj   +1 more source

Cloning and molecular analysis of L-asparaginase II gene (ansB) [PDF]

, 2015
The deamination of L-asparagine to L-aspartic acid and ammonia is catalyzed by L-asparaginases (L-asparagine amino hydrolase). The enzyme L-asparaginase is widely distributed in nature from different living organisms, starting from bacteria till mammals ...
SHERIF M. ELNAGDY, ALAA EDDEEN SEUFI, MOHAMED GAMAL, ZEINAT K. MOHAMED   +3 more
core  

Erythrocytes as Carriers for L-Asparaginase. Methodological and Mouse In-vivo Studies

, 1990
L-Asparaginase has been encapsulated in Swiss mouse or human erythrocytes by hypotonic haemolysis followed by isotonic resealing and reannealing. The details of incorporation and properties of carrier erythrocytes are presented.
M Chassaigne, J P Muh, C Ropars, M Laguerre, R Kravtzoff   +4 more
core   +1 more source

L-asparaginase-antileukemia agent.

JPMA. The Journal of the Pakistan Medical Association, 1977
This paper is an extension of a previous report (Yaqub 1975). Our interest in L-asparaginase is increasing due to the recognition of the fact that it is a best tool against leukemia. In this paper we have tried to discuss (in view of research work, 1973-75) its basic characteristics and its practicability of successfully being used as an antitumour ...
A, Jabbar, M, Yaqub
openaire   +2 more sources