Results 101 to 110 of about 22,972 (221)

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]

, 2019
In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert, D'Hont, Jinke, Demoen, Lisa, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Hochepied, Tino, Lammens, Tim, Lemeire, Kelly, Lintermans, Béatrice, Matthijssens, Filip, Pedro Pinto De Almeida, André, Pieters, Tim, Reunes, Lindy, T'Sas, Sara, Van Vlierberghe, Pieter, Vanrockeghem, Frédérique   +16 more
core   +3 more sources

Phagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein–Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study

Diagnostic Cytopathology, Volume 54, Issue 5, Page E136-E139, May 2026.
ABSTRACT Phagocytic activity of mesothelial cells is a rare phenomenon requiring careful differentiation from histiocytic hemophagocytosis to ensure appropriate patient management, as these phenomena could exhibit distinct clinical implications. In this study, we report a case of phagocytic mesothelial cells found in pericardial effusion that developed
Hidetoshi Satomi, Ayumi Ryu, Sei Murayama, Hiroya Kojima, Satoshi Tanada, Keiichiro Honma   +5 more
wiley   +1 more source

Screening and assay of extracellular enzymes in Phomopsis azadirachtae causing die-​back disease of neem [PDF]

, 2013
Phomopsis azadirachtae is the causal agent of destructive die-​back disease of neem. The mol. mechanism of pathogenicity is not clear. Pectinases, cellulases, hemicellulases and ligninases have been extensively studied because of their plant cell wall ...
Lakshmeesha, T.R., Mohammed Shafi Sofi, ., Sateesh, M.K., Vedamurthy, A.K., Vedashree, S.   +4 more
core  

From Power‐Law to Correlation‐Time Distributions: A Unified Framework for the Analysis of Nuclear Magnetic Relaxation Dispersion (NMRD) Profiles of Complex Biological Systems

Magnetic Resonance in Chemistry, Volume 64, Issue 5, Page 494-505, May 2026.
1H NMRD profiles of biological systems often follow a power‐law dependence rather than a Lorentzian dispersion. This behavior can arise from a broad distribution of correlation times, weighted by 1/τ 1−α. Validated across diverse systems such as sedimented proteins and biological tissues, this framework provides a physical interpretation of power‐law ...
Giacomo Parigi, Adam Kubrak
wiley   +1 more source

Allergic-like reactions to asparaginase: Atypical allergies without asparaginase inactivation [PDF]

, 2016
Background: Asparaginase is an important component of pediatric acute lymphoblastic leukemia (ALL) therapy. Unfortunately, this treatment is hampered by hypersensitivity reactions.
Escherich, G. (Gabriele), Kloos, R.Q.H. (Robin), Pieters, R. (Rob), Sluis, I.M. (Inge) van der   +3 more
core   +2 more sources

The Contribution to the Assignment of Defined Daily Dose (DDD) to Antineoplastic Drugs of the Italian Working Group on DDD

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Purpose To report the experience of the Italian Working Group on DDD (Ita‐DDD‐wg) in assigning DDDs to a list of antineoplastic agents. Methods Active substances from the ATC L01 group with no assigned DDD and reimbursed at least once during 2021 by the Italian Healthcare Service were identified.
Angela Boccia, Giulia Hyeraci, Anna Girardi, Rosa Gini, Gianluca Trifirò, Ylenia Ingrasciotta, Andrea Spini, Valentina Ientile, Elisabetta Poluzzi, Giampiero Mazzaglia, Ippazio Cosimo Antonazzo, Casula Manuela, Elena Tragni, Olivia Leoni, Arianna Mazzone, Michele Ercolanoni, Martina Zanforlini, Ursula Kirchmayer, Belleudi Valeria, Marco Finocchietti, Francesco Barone‐Adesi, Giuseppe Roberto   +21 more
wiley   +1 more source

Isolation and Identification of L-asparaginase producing Erwinia strains which isolated from Potato Farms

Biological Journal of Microorganism, 2016
Introduction: L-Asparaginase can be effectively used for the treatment of lymphoblastic leukemia. The rapid growth of cancer cells are needed for L-asparagine abundant storage.
Arastoo Badoei-Dalfard, Zahra Karami, Narjes Ramezani–pour   +2 more
doaj  

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, Volume 208, Issue 5, Page 1572-1583, May 2026.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115

BMC Pharmacology and Toxicology, 2018
Background L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of hypersensitivity in the long-term
Noura El-Ahmady El-Naggar, Sahar F. Deraz, Sara M. El-Ewasy, Ghada M. Suddek   +3 more
doaj   +1 more source

Three Distinct Species Cause Bacterial Leaf Spots in ‘Ubá’ Mango in Zona da Mata, Minas Gerais, Brazil

Journal of Phytopathology, Volume 174, Issue 3, May/June 2026.
ABSTRACT ‘Ubá’ mango is a fruit crop of great value for farmers in the Zona da Mata region of Minas Gerais state, Brazil. Organic farmers from this region recently reported a severe outbreak of foliar black spots of unknown aetiology in orchards of this mango variety, causing significant concern.
Nikolas Emanuel Chaves‐Silva, Adryelle Anchieta Sousa, Sandro Lúcio Silva Moreira, Camila Mota De Assis Figueiredo, Cleverson Vieira Pires, Mateus Pereira Gonzatto, Alex Gazolla de Castro, Marcos Rogério Tótola, Jorge Luis Badel   +8 more
wiley   +1 more source