Results 101 to 110 of about 10,199,072 (234)

Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115

BMC Pharmacology and Toxicology, 2018
Background L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of hypersensitivity in the long-term
Noura El-Ahmady El-Naggar, Sahar F. Deraz, Sara M. El-Ewasy, Ghada M. Suddek   +3 more
doaj   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Anticancer Activity of L-Asparaginase Produced from Vigna Unguiculata

, 2018
The present study aimed to production of purified L-asparaginase from Vignaunguiculata. Different physiological parameters, such as pH, temperature and incubation period, were optimized for growth and maximum L-asparaginase production.
Moharib, Sorial A., Sorial A. Moharib
core   +1 more source

Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study

Revista Brasileira de Hematologia e Hemoterapia
Background l-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-l-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity
Gabriela Galindo-Rodríguez, José C. Jaime-Pérez, Mario C. Salinas-Carmona, Sandra N. González-Díaz, Ángeles Castro-Corona, Raúl Cavazos-González, Humberto Treviño-Villarreal, Alberto C. Heredia-Salazar, David Gómez-Almaguer   +8 more
doaj   +1 more source

Case Series: Can Daily Patient‐Reported Outcome Measures Be Implemented for Cancer‐Related Fatigue?

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Cancer‐related fatigue (CrF), a prevalent and debilitating symptom among cancer patients, remains underrecognized and unstandardized in routine oncology care. To address this, we introduced a new digital tool for daily CrF measurement and integration in routine cancer treatment.
Alexander Tilg, Andreas Meryk, Johannes G. Weiss, Roman Crazzolara   +3 more
wiley   +1 more source

Foodborne Carcinogens: Formation Pathways, Health Risks, and Cutting‐Edge Physical and Chemical Prevention Strategies

eFood, Volume 7, Issue 3, June 2026.
This review highlights the formation of foodborne carcinogens during processing and evaluates different mitigation strategies, including natural antioxidants and modern cooking techniques, to reduce associated cancer risks and enhance food safety. ABSTRACT Food processing methods, though vital for improving food safety, taste, and shelf life, can ...
Naglaa S. Ashmawy, Ahmed A. Zaky, Noha H. Badr, Ali Korin, Mohamed A. Farag   +4 more
wiley   +1 more source

Peripheral T‐Cell Lymphomas in Southern Taiwan: Epidemiology, Treatment Patterns, and Long‐Term Outcomes

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Peripheral T‐cell lymphomas (PTCLs) are heterogeneous neoplasms with poor prognosis and marked geographic variation. Data from Taiwan remain limited. We conducted a 15‐year retrospective cohort study of 249 patients diagnosed with PTCL at two major centers in southern Taiwan between 2010 and 2024 to characterize regional epidemiology, real ...
Bo‐Yu Huang, Li‐Chang Chang, Sheng‐Yen Hsiao, Ya‐Ping Chen, Sin‐Syue Li, Pei‐An Fu, Chen Chang, Kung‐Chao Chang, Tsai‐Yun Chen, Ya‐Ting Hsu   +9 more
wiley   +1 more source

Thermodynamic study of enzyme activity and thermostability

, 2014
Since enzyme production is strongly influenced by temperature (T), knowledge of thermodynamic quantities of L-asparaginase (ASPase) activity and thermostability is useful to characterize the enzyme as well as to evaluate the feasibility of its industrial
CONVERTI, ATTILIO
core  

Durable MRD‐Negative Remission With Blinatumomab and Venetoclax in Heavily Pretreated Relapsed/Refractory Philadelphia Chromosome‐Positive Acute Lymphoblastic Leukemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Tyrosine kinase inhibitors (TKIs) are standard therapy for Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapsed or refractory disease remains challenging due to resistance driven by ABL kinase domain mutations.
Mohammad Shahzaib Qadir, Shereen Farooq, Omer Jamy   +2 more
wiley   +1 more source

Production of L-asparaginase through biodegradation of chicken bone wastes [PDF]

, 2017
L-asparaginase is highly demanded in pharmaceutical, food and biosensor industry due to its remarkable properties in hydrolysing L-asparagine into aspartic acid and ammonia.
Chia, Vi Vien
core