Results 81 to 90 of about 13,701 (185)

Recent progress on the development of nanoparticulate L-asparaginase for enhanced anti-cancer activity

Cancer Nanotechnology
Background L-Asparaginase is a medically important enzyme known to be a chemotherapeutic agent and is often used in multi-agent chemotherapeutic regimens.
Sahand Mazloum-Ravasan, Hamed Hamishehkar   +1 more
doaj   +1 more source

L-asparaginase-antileukemia agent.

JPMA. The Journal of the Pakistan Medical Association, 1977
This paper is an extension of a previous report (Yaqub 1975). Our interest in L-asparaginase is increasing due to the recognition of the fact that it is a best tool against leukemia. In this paper we have tried to discuss (in view of research work, 1973-75) its basic characteristics and its practicability of successfully being used as an antitumour ...
A, Jabbar, M, Yaqub
openaire   +2 more sources

BCL‐2 and MCL1 co‐inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A‐rearranged acute lymphoblastic leukaemia

British Journal of Haematology, Volume 209, Issue 2, Page 786-792, August 2026.
Mawar Karsa, Ayu Karsa, Dayna Spurling, Lin Xiao, Emma Ronca, Angelika Bongers, Weiman Gao, Andrew J. Gifford, Ali El‐Ayoubi, Laurence C. Cheung, Rishi S. Kotecha, Richard B. Lock, Charis E. Teh, Guillaume Lessene, Murray D. Norris, Andrew Wei, Michelle Haber, Michelle J. Henderson, Donia M. Moujalled, Klaartje Somers   +19 more
wiley   +1 more source

Cytotoxicity of L-asparaginase from eucaryotic Cladosporium species against breast and colon cancer in vitro

Journal of the Egyptian National Cancer Institute
Background Recent statistical analyses indicate a rapid increase in the incidence of breast and colon cancer in Egypt. Although invasive techniques have been widely employed for early detection, diagnosis, and intervention of those cancers, they are ...
Dina Johar, Hamido M. Hefny, Moselhy S. Mansy, Amal A. I. Mekawey, Mohammed S. Abdulrahman, Samy Zaky   +5 more
doaj   +1 more source

Fungal L-Asparaginase from environmental isolates with antimicrobial and antibiofilm activities. [PDF]

AMB Express
Khalifa BA, Hashem ZS, Hisham M, Khedr EH, Abdelhameed SM.   +4 more
europepmc   +1 more source

Overcoming challenges in the production of a human-like L-asparaginase: advanced strategies for expression and purification. [PDF]

Biotechnol Rep (Amst)
Pinheiro MP, Guimarães AVF, de Freitas LA, Furtado GP, Lourenzoni MR, Medeiros MA.   +5 more
europepmc   +1 more source

Biochemical characterisation of a new thermotolerant L-asparaginase produced by Cunninghamella echinulata PA3S12MM isolated from the Atlantic Forest. [PDF]

Arch Microbiol
Von Groll S, da Silva LC, Souza PHN, da Silva WJ, Bifano TD, Silva JLDC, Simão RCG, Simão, Kadowaki MK, Maller A.   +9 more
europepmc   +1 more source

Prevention of Subsequent L-Asparaginase Hypersensitivity in Children Through Premedication: A Single-Center Experience. [PDF]

J Pediatr Pharmacol Ther
Saligupta P, Choed-Amphai C, Sathitsamitphong L, Lao-Araya M.   +3 more
europepmc   +1 more source

Streptomyces koyangensis L-asparaginase: computational prediction of dual-mechanism BCL-2 interaction in acute lymphoblastic leukemia. [PDF]

Sci Rep
Solanki G, Prajapati C, Gadhvi R, Kamble L, Sharma MC, Hajare ST.   +5 more
europepmc   +1 more source

Characterization and bioactivities of glutaminase-free L-asparaginase from Salinicola acorporae S4-41. [PDF]

Microb Cell Fact
El-Shanshoury AER, Abosamra HH, Elsakhawy T.   +2 more
europepmc   +1 more source