Results 81 to 90 of about 14,268,580 (205)

L-asparaginase induces IP3R-mediated ER Ca2+ release by targeting µ-OR1 and PAR2 and kills acute lymphoblastic leukemia cells

open access: yesCell Death Discovery
L-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a hematologic cancer that claims the most lives of pediatric cancer patients.
Jung Kwon Lee   +2 more
doaj   +1 more source

Reduced‐dose pegylated asparaginase reliably achieves therapeutic levels in adult patients with acute lymphoblastic leukaemia and lymphoblastic lymphoma

open access: yes
British Journal of Haematology, EarlyView.
Leah A. Goldberg   +14 more
wiley   +1 more source

Optimization of asparaginase production from Zymomonas mobilis by continuous fermentation

open access: yesActa Scientiarum: Biological Sciences, 2016
Asparaginase is an enzyme used in clinical treatments as a chemotherapeutic agent and in food technology to prevent acrylamide formation in fried and baked foods.
Francieli Bortoluzzi Menegat   +3 more
doaj   +1 more source

Isolasi Dan Karakterisasi Ekstrak Kasar L-Asparaginase Dari Bakteri Simbion Spons Dan Aplikasinya Sebagai Antimikroba

open access: yes, 2017
L-asparagianse (L-aspargin amino hydrolase, E.C.3.5.1.1) adalah enzim yang mengkatalisis L-asparagin menjadi asam L-aspartat dan amonia. Penelitian ini bertujuan untuk mengetahui aktivitas enzim L-asparaginase yang berasal dari mikroba simbion spons dan ...
Natsir, Hasnah   +2 more
core  

Production, Optimization and Characterization of L-asparaginase from Endophytic Fusarium oxysporum Strain MJS2, an Isolate of Mirabilis jalapa [PDF]

open access: yes
L-asparaginase is an extremely demanding biocatalyst that is employed to treat acute lymphoblastic leukemia (ALL) and lessen the development of acrylamide in fried food products. Here, an endophytic F. oxysporum MJS2, obtained from the stem tissues of M.
Hiran Kanti Santra   +2 more
core   +1 more source

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

open access: yes, 2012
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
core  

INFLUENCE OF GLUCOSE AND L-ASPARAGINE CONCENTRATIONS ON L-ASPARAGINASE PRODUCTION BY ENDOPHYTIC FUNGI [PDF]

open access: yes, 2017
In this study, five L-asparaginase–producing endophytes (ODL4, PBS1, PBL13, CCL1, MKS1) were evaluated for their L-asparaginase production when cultivated in various glucose (0, 0.5, 1, 2, 3, 4, 5 %) and L-asparagine (0, 5, 10, 20, 30, 40, 50 mM ...
Adeline Su Yien Ting   +3 more
core   +1 more source

Isolation and Identification of L-asparaginase producing Erwinia strains which isolated from Potato Farms

open access: yesBiological Journal of Microorganism, 2016
Introduction: L-Asparaginase can be effectively used for the treatment of lymphoblastic leukemia. The rapid growth of cancer cells are needed for L-asparagine abundant storage.
Arastoo Badoei-Dalfard   +2 more
doaj  

Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115

open access: yesBMC Pharmacology and Toxicology, 2018
Background L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of hypersensitivity in the long-term
Noura El-Ahmady El-Naggar   +3 more
doaj   +1 more source

L-asparaginase II Production by Escherichia coli [PDF]

open access: yes, 1985
Growth of Escherichia coli A-l under aerobic conditions in an enriched medium with a total amount of 0.2 per cent glucose was biphasic and asparaginase II activity was detected after depletion of ammonia from the growth medium in the second phase of ...
Johnson, Terrance L. (Terrance Lewyne), 1950-
core  

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