Results 81 to 90 of about 10,199,072 (234)

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Molecular phylogenetic characterization of L-asparaginase-producing endophytic fungi inhabiting Prunus africana and Periploca linearifolia: Effect of incubation time and pH on enzyme production

Scientific African
The therapeutic use of L-asparaginase derived from bacterial sources has been constrained by various challenges, including toxicity and repression. This has prompted the exploration of alternative sources, particularly eukaryotic microorganisms like ...
Dennis Kipngenoh Cheruiyot, George Isanda Omwenga, Eliud Nyaga Mwaniki Njagi   +2 more
doaj   +1 more source

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source

Production, Optimization and Characterization of L-asparaginase from Endophytic Fusarium oxysporum Strain MJS2, an Isolate of Mirabilis jalapa

L-asparaginase is an extremely demanding biocatalyst that is employed to treat acute lymphoblastic leukemia (ALL) and lessen the development of acrylamide in fried food products. Here, an endophytic F. oxysporum MJS2, obtained from the stem tissues of M.
Hiran Kanti Santra, Debdulal Banerjee, Sani Sen   +2 more
core   +1 more source

Gene sequencing, cloning, and expression of the recombinant L- Asparaginase of Pseudomonas aeruginosa SN4 strain in Escherichia coli

Biological Journal of Microorganism, 2016
Introduction: L- asparaginase is in an excessive demand in medical applications and in food treating industries, the request for this therapeutic enzyme is growing several folds every year.
Arastoo Badoei-dalfard, Zahra Karami, Narjes Ramezani-pour   +2 more
doaj  

L-asparaginase induces IP3R-mediated ER Ca2+ release by targeting µ-OR1 and PAR2 and kills acute lymphoblastic leukemia cells

Cell Death Discovery
L-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a hematologic cancer that claims the most lives of pediatric cancer patients.
Jung Kwon Lee, Hamza Kamran, Ki-Young Lee   +2 more
doaj   +1 more source

Artificial Cells: Perspective on Reconstructing Biological Cells and “Out of the Box” Innovations

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
The first artificial cell was artificial red blood cells (RBCs) (Chang, 1957), RBC is one of the most important cells because our cells, tissues, organs, and whole human being need it for survival. Even more exciting is innovating this to result in artificial cells of unlimited configurations, contents, and applications.
Thomas Ming Swi Chang
wiley   +1 more source