Results 71 to 80 of about 2,165 (162)

The pathogenesis of, and pharmacological treatment for, Canavan disease. [PDF]

Drug Discov Today, 2022
Wei H, Moffett JR, Amanat M, Fatemi A, Tsukamoto T, Namboodiri AM, Slusher BS.   +6 more
europepmc   +1 more source

Clustering of Juvenile Canavan disease in an Indian community due to population bottleneck and isolation: genomic signatures of a founder event. [PDF]

Eur J Hum Genet, 2023
Kotambail A, Selvam P, Muthusamy K, Thomas M, Sudhakar SV, Ghati C, Danda S, Arunachal G.   +7 more
europepmc   +1 more source

LncRNA CRNDE promotes hepatoma cell proliferation by regulating the metabolic reprogramming of M2 macrophages via ERK pathway

Cancer Cell International
Background LncRNA colorectal neoplasia differentially expressed (CRNDE) was found to be an important regulator in many cancers. This project focuses on the function of CRNDE on macrophage metabolic reprogramming and Hepatocellular carcinoma (HCC). Method
Chao Lin, Tao Jiang, Changyong E, Lun Wang, Tong Chen, Xia Wang, Yien Xiang   +6 more
doaj   +1 more source

Левкодистрофии и левкоенцефалопатии в детската възраст – актуална класификация, диагностициране и лечение

Българска неврология, 2020
Левкодистрофиите и левкоенцефалопатиите са редки генетични прогресиращи заболявания на нервната система с начало в детската възраст с нарушен миелинов синтез в централната нервна система (ЦНС), по-рядко и в периферните нерви. Актуалната им класификация,
Veneta Bojinova, I. Milanov, A. Todorova, T. Todorov, N. Topalov   +4 more
doaj  

Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice. [PDF]

Ann Neurol, 2021
Wang Y, Hull V, Sternbach S, Popovich B, Burns T, McDonough J, Guo F, Pleasure D.   +7 more
europepmc   +1 more source

The epidemiology of irritable bowel syndrome

Clinical Epidemiology, 2014
Caroline Canavan, Joe West, Timothy Card Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK Abstract: Irritable bowel syndrome (IBS) is a functional condition of the bowel that is diagnosed using clinical criteria. This
Canavan C, West J, Card T
doaj  

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement

International Journal of COPD, 2020
Ayushman Gupta, 1 Leah R Jayes, 2 Steve Holmes, 3 Opinder Sahota, 4 Melissa Canavan, 5 Sarah L Elkin, 6 Kelvin Lim, 7 Anna C Murphy, 8 Sally Singh, 9, 10 Elizabeth A Towlson, 11 Helen Ward, 12 Jane Scullion, 9 Tricia M McKeever, 2 Charlotte E Bolton 1 ...
Gupta A, Jayes LR, Holmes S, Sahota O, Canavan M, Elkin SL, Lim K, Murphy AC, Singh S, Towlson EA, Ward H, Scullion J, McKeever TM, Bolton CE   +13 more
doaj  

N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes

Cell Communication and Signaling
Background Microglia play a crucial role in brain development and repair by facilitating processes such as synaptic pruning and debris clearance.
Federica Felice, Pamela De Falco, Martina Milani, Serena Castelli, Antonella Ragnini-Wilson, Giacomo Lazzarino, Nadia D’Ambrosi, Fabio Ciccarone, Maria Rosa Ciriolo   +8 more
doaj   +1 more source

Cribriform Appearance of White Matter in Canavan Disease Associated with Novel Mutations of ASPA Gene. [PDF]

J Pediatr Genet, 2022
Bhat MD, Manjunath N, Kumari R, Faruq M, Pal PK, Prasad C, Mundlamuri RC, Nalini A, Udupi GA, Baishya PP, Kulanthaivelu K.   +10 more
europepmc   +1 more source

High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease. [PDF]

ACS Chem Neurosci, 2021
Nešuta O, Thomas AG, Alt J, Hin N, Neužilová A, Long S, Tsukamoto T, Rojas C, Wei H, Slusher BS.   +9 more
europepmc   +1 more source