Results 101 to 110 of about 6,619,981 (269)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Automatic detection and classification of lung cancer CT scans based on deep learning and ebola optimization search algorithm

, 2023
Tehnan I. A. Mohamed, Olaide N. Oyelade, Absalom E. Ezugwu   +2 more
openalex   +2 more sources

Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter‐ and Intracellular Regulation [PDF]

, 2022
Ruo‐Can Qian, Ze‐Rui Zhou, Yuting Wu, Zhenglin Yang, Weijie Guo, Dawei Li, Yi Lu   +6 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Plasma carotenoids and risk of breast cancer over 20 y of follow-up [PDF]

, 2015
A. Heather Eliassen, Xiaomei Liao, Bernard Rosner, Rulla M. Tamimi, Shelley S. Tworoger, Susan E. Hankinson   +5 more
openalex   +1 more source

A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence [PDF]

, 2023
Hong‐Wei An, Da‐Yong Hou, Jia Yang, Ziqi Wang, Man‐Di Wang, Rui Zheng, Ni-Yuan Zhang, Xingjie Hu, Zhijia Wang, Lu Wang, Di Liu, Hao Junfeng, Wanhai Xu, Yuliang Zhao, Hao Wang   +14 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer [PDF]

, 2014
Svetlana Fayngerts, Jianping Wu, Camilla L. Oxley, Xianglan Liu, Anastassios Vourekas, Terry Cathopoulis, Zhaojun Wang, Jian Cui, Suxia Liu, Honghong Sun, Mark A. Lemmon, Lining Zhang, Yigong Shi, Youhai H. Chen   +13 more
openalex   +1 more source

Trends in Epidemiology of Esophageal Cancer in the US, 1975-2018 [PDF]

, 2023
Gladys M. Rodriguez, Dylan DePuy, Mayada Aljehani, Jeffrey Bien, Jerry Lee, David H. Wang, Albert Y. Lin   +6 more
openalex   +1 more source