Results 161 to 170 of about 3,905,688 (260)

Increasing Burden of Early-Onset Cancers: Disentangling the Contributions of Changes in Risk from Demographic Shifts. [PDF]

Cancer Res Commun
Braggion A, van der Linden BWA, Tancredi S, Rohrmann S, Cullati S, Chiolero A.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Accelerometry-measured prolonged and interrupted sedentary behavior and cancer incidence and mortality: A cohort study of 91,292 UK Biobank participants. [PDF]

PLoS Med
Zhou Z, Trost SG, Ryde GC, Parra-Soto S, Fang Z, Xu C, Lu Y, Wang K, Du M, Li Z, Lv Y, Gill JMR, Gray SR, Celis-Morales C, Gunter MJ, Giovannucci E, Pell JP, Song M, Ho FK.   +18 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Stroke Recurrence and Long-Term Mortality in Patients Diagnosed with Cancer Following Stroke. [PDF]

Yonsei Med J
Choi JK, Kim YD, Nam HS, Kim DY, Lee HS, Heo JH.   +5 more
europepmc   +1 more source

Cancer [PDF]

, 2005
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Immune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer. [PDF]

Clin Cancer Res
Yang DD, Abdelnaser A, Haas AJ, Wala J, Barney AA, Saad E, Crowdis JP, Ricker CA, Awad S, Gurel B, Park J, King MT, Nguyen PL, Choueiri TK, Einstein DJ, Balk SP, Tewari AK, de Bono JS, Salari K, Taplin ME, Wu CL, Van Allen EM.   +21 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis. [PDF]

EBioMedicine
Xu Q, Niu L, Cao Z, Geng J, Yang H, Zeng Y, Zhang Y, Li Q, Suo C, Yuan G, Song H, Hou C.   +11 more
europepmc   +1 more source