Results 61 to 70 of about 9,858,231 (365)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The present and future opportunities of the Rare Cancer Network: an international consortium for advancement of oncologic care

open access: yesRare Tumors, 2015
To date, the Rare Cancer Network (RCN) has initiated more than 90 studies and 54 peer-reviewed publications were produced as a result. The Second International Symposium of the Rare Cancer Network recently took place in Istanbul, Turkey on April 17-18 ...
The Rare Cancer Network
doaj   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

open access: yesFEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard   +7 more
wiley   +1 more source

The 150 most important questions in cancer research and clinical oncology series: questions 86–93

open access: yesChinese Journal of Cancer, 2018
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all ...
Chinese Journal of Cancer
doaj   +1 more source

Multi-Criteria Measurement of AI Support to Project Management

open access: yesIEEE Access, 2023
This paper aims to measure the level of artificial intelligence (AI) support to project management (PM) in selected service sector activities. The exploratory factor analysis was employed based on the extensive survey on AI in Slovenian companies and the
Vesna Cancer, Polona Tominc, Maja Rozman
doaj   +1 more source

Predictive factors associated with survival rate of cervical cancer patients in Brunei Darussalam [PDF]

open access: yesBrunei Int Med J. 2019; 15:125-132, 2021
Introduction: Cervical cancer is the third most prevalent cancer among women in Brunei Darussalam. This study aims to report the overall survival rates and associated factors of patients diagnosed with malignant cervical cancer in Brunei Darussalam. Methods: A retrospective study of patients diagnosed with cervical cancer from 2007 to 2017 in Brunei ...
arxiv  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

open access: yesFEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti   +2 more
wiley   +1 more source

A comprehensive review of deep learning in lung cancer [PDF]

open access: yesarXiv, 2023
To provide the reader with a historical perspective on cancer classification approaches, we first discuss the fundamentals of the area of cancer diagnosis in this article, including the processes of cancer diagnosis and the standard classification methods employed by clinicians.
arxiv  

Cancer Report 2008 [PDF]

open access: yes, 2008
Welcome Letter by the Directors of the Cancer Center 2-3 Stories from cancer survivors 4-5 Prostate Cancer 6-7 Kidney Cancer 8 Bladder Cancer 9 Activity Report 10-11 Cancer Research 12-13 Retirees 13 Quality Cancer Care 14-15 Survivorship 16 CLIMB ...
Coborn Cancer Center
core   +1 more source

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

open access: yesFEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang   +9 more
wiley   +1 more source

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