Results 231 to 240 of about 3,139,231 (313)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Correction: Physical activity barriers, facilitators, and preferences in primary and tertiary prevention of breast cancer: a French national observational study. [PDF]

J Cancer Surviv
Fournier B, Delrieu L, Vallance J, Phillips S, Noh H, Gouez M, Herman F, Hamy-Petit AS, Seintinelles Research Network, Perol O, Reyal F, Fervers B.   +11 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Additional file 3 of Peripheral lymphocyte count as a prognostic marker in cervical cancer patients treated with immune checkpoint inhibitors: a retrospective study

Dofutsu, Mihoko, Aichi, Masahiro, Itai, Toshiyuki, Shinoda, Satoru, Kamiya, Natsuko, Cho, Tamaki, Ogawara, Yuki, Ishidera, Yumi, Imai, Yuichi, Miyagi, Etsuko, Mizushima, Taichi   +10 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Dihydrocapsaicin Secreted by RYK Silenced Bone Marrow-Derived Mesenchymal Stem Cells Triggers Apoptosis of Gastric Cancer Cells. [PDF]

Cancer Manag Res
Fu Y, Cai Z, Wang Y, Huang M, Huang J.
europepmc   +1 more source

Discovery ofNovel Potent Triple IKZF1/2/3 Degradersfor the Treatment of Hematological Cancers

Ting Wei (113015), Shiyang Sun (588807), Xiaotong Hu (558839), Pengli Wei (14641202), Zhiya Fan (9411634), Jian Yan (49839), Yalei Wang (669779), Zhenze Qi (21726058), Changkai Jia (21726052), Yaqiu Mao (21726055), Tingting Yang (166111), Xu Cai (5326745), Bingkun Li (9752768), Zhiyuan Zhao (1400806), Min Qiao (111120), Yaxin Zou (21726061), Weijie Qin (1694185), Xuesong Feng (754835), Hongzhou Shang (21929961), Pengyun Li (2685118), Zhibing Zheng (9716361), Song Li (65582)   +21 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retraction Note: LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway. [PDF]

J Exp Clin Cancer Res
Liu B, Pan S, Xiao Y, Liu Q, Xu J, Jia L.   +5 more
europepmc   +1 more source