Results 241 to 250 of about 3,550,326 (312)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The PI3K/AKT signaling networks in cancer glucose metabolism: mechanisms and therapeutic implications. [PDF]

Transl Oncol
Cheng S, Jiang Q, Huang H, Tong H, Xie M.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Patient-reported outcomes and health-related quality of life in individuals living with, through, and beyond cancer in Sweden: a cross-sectional study. [PDF]

J Patient Rep Outcomes
Borg S, Rosell L, Garpenhag L, Calling S, Larsson AM.   +4 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany. [PDF]

J Cancer Res Clin Oncol
Ernst P, Rachow T, Henn S, Hammersen JF, Dittrich S, Heßmer A, Hillig A, Heßmer A, Hochhaus A.   +8 more
europepmc   +1 more source

Polygenic risk scores for premagnetic resonance imaging risk stratification in men with clinically suspected prostate cancer. [PDF]

J Natl Cancer Inst
Fischer MP, Mayer A, Braun A, Kraft J, Hansen CM, Baumgärtner GL, Asbach P, Padhani AR, Penzkofer T, König F, Awasthi S, Makowski MR, Ripke S, Hamm CA.   +13 more
europepmc   +1 more source