Results 151 to 160 of about 31,418 (244)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Increased Expression of <i>Serca2b</i> in the Adipose Tissue of a Cancer Cachexia Model. [PDF]

In Vivo
Kasai S, Sato S, Namiki K, Obata R, Yoshizawa K.   +4 more
europepmc   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Revisiting insulin resistance in human cancer cachexia - a systematic review and meta-analysis. [PDF]

Acta Oncol
Sørensen J, Hammershøi A, Màrmol JM, Lehrskov LL, Nørgaard O, Sylow L.   +5 more
europepmc   +1 more source

Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Bulletin of the Korean Chemical Society, EarlyView.
This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
wiley   +1 more source

Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis. [PDF]

BJC Rep
Degraeve AL, Cutignano A, Piscitelli F, Villano R, De Simone G, Verde R, Thibaut MM, Bindels LB, Di Marzo V.   +8 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential. [PDF]

J Transl Med
Wei S, Lv X, Xu Y, Ding S.
europepmc   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Neuroinflammation drives apathy in cancer cachexia. [PDF]

Cancer Commun (Lond)
Ha B, Cao X.
europepmc   +1 more source