Results 41 to 50 of about 18,416,887 (403)
Enhanced Cellular Uptake and Pharmacokinetic Characteristics of Doxorubicin-Valine Amide Prodrug
Molecules, 2016 In this study, we synthesized the valine (Val)-conjugated amide prodrug of doxorubicin (DOX) by the formation of amide bonds between DOX and Val. The synthesis of the DOX-Val prodrug was identified by a proton nuclear magnetic resonance (1H-NMR) assay ...
Yohan Park +9 more
doaj +1 more source
Diagnosis and treatment of the Cancer Tumor Cells (CTCs); Capturing and Diagnosing Kits [PDF]
Nanomedicine Research Journal, 2019 Objective(s): In the developed countries, one of the leading causes of death is cancer. Cancer cells with their unique and destructive characteristics impose high costs on communities.
Ali Alirezaie Alavijeh +3 more
doaj +1 more source
Hallmarks of Cancer: New Dimensions.
Cancer Discovery, 2022 The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles.
D. Hanahan
semanticscholar +1 more source
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities [PDF]
, 2014 SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.
Chiao, Christine Ya-Chi +6 more
core +2 more sources
Biomedicines, 2021 MicroRNAs (miRNAs) are short non-coding RNA involved in the regulation of specific mRNA translation. They participate in cellular signaling circuits and can act as oncogenes in tumor development, so-called oncomirs, as well as tumor suppressors. miR-7 is
Petra Korać +2 more
doaj +1 more source
A guide to cancer immunotherapy: from T cell basic science to clinical practice
Nature reviews. Immunology, 2020 The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer.
A. Waldman, Jill M. Fritz, M. Lenardo
semanticscholar +1 more source
Pharmaceutics, 2022 Promising results in clinical studies have been demonstrated by the utilization of electrothermal agents (ETAs) in cancer therapy. However, a difficulty arises from the balance between facilitating the degradation of ETAs, and at the same time ...
Maria P. Meivita +7 more
doaj +1 more source
Mutational drivers of cancer cell migration and invasion
British Journal of Cancer, 2020 Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations determine cancer cell fate by affecting cell proliferation, apoptosis and immune response, and increasing data show that mutations are involved in metastasis, a ...
N. M. Novikov +3 more
semanticscholar +1 more source
The real war on cancer: the evolutionary dynamics of cancer suppression. [PDF]
, 2012 Cancer is a disease of multicellular animals caused by unregulated cell division. The prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer results after a series of (generally somatic) mutations that knock out the ...
Nunney, Leonard
core +1 more source
Stem cell-like cancer cells in cancer cell lines
Cancer Biomarkers, 2007 Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Moreover, a small number of cancer cells express stem cell markers, including CD133 and ATP-binding cassette transporters, by which the cells can pump out specific fluorescence dyes, such as Hoechst33342, as well as anti-cancer drugs, suggesting that either cancer ...
openaire +4 more sources