Results 41 to 50 of about 16,222,859 (319)

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

The Continuous Concentration of Particles and Cancer Cell Line Using Cell Margination in a Groove-Based Channel

Micromachines, 2017
In the capillary venules, blood cells auto-separate with red blood cells aggregating near the centre of vessel and the nucleated cells marginating toward the wall of vessel. In this experiment, we used cell margination to help enrich the Jurkat cells via
Sheng Yan, Dan Yuan, Qianbin Zhao, Jun Zhang, Weihua Li   +4 more
doaj   +1 more source

Bidirectional Mechanical Response Between Cells and Their Microenvironment

Frontiers in Physics, 2021
Cell migration and invasion play a role in many physiological and pathological processes and are therefore subject of intensive research efforts. Despite of the intensively investigated biochemical processes associated with the migration and invasion of ...
Claudia Tanja Mierke
doaj   +1 more source

Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping

Journal of Cancer, 2017
Breast cancer cell lines have been widely used for breast cancer modelling which encompasses a panel of diseases with distinct phenotypical associations.
Xiaofeng Dai, Hongye Cheng, Zhonghu Bai, Jia Li   +3 more
semanticscholar   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Chinese Expert Consensus on Assessment and Clinical Application of 
Tertiary Lymphoid Structure for Non-small Cell Lung Cancer (2025 Version)

Chinese Journal of Lung Cancer
The tertiary lymphoid structure (TLS) plays a crucial role in the tumor microenvironment, influencing tumor development and progression. As an emerging biomarker for predicting the prognosis and treatment response in cancer patients, TLS has received ...
Lung Cancer Collaboration Group of Tumor Pathology Committee of Chinese Anti-Cancer Association, Expert Committee on Non-small Cell Lung Cancer of Chinese Society of Clinical Oncology   +1 more
doaj   +1 more source

Genetic and transcriptional evolution alters cancer cell line drug response

Nature, 2018
Human cancer cell lines are the workhorse of cancer research. Although cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied.
U. Ben-David, B. Siranosian, G. Ha, Helen Tang, Yaara Oren, Kunihiko Hinohara, C. Strathdee, Joshua M. Dempster, Nicholas J. Lyons, Robert T. Burns, Anwesha Nag, G. Kugener, B. Cimini, Peter Tsvetkov, Y. Maruvka, Ryan O’Rourke, Anthony J. Garrity, Andrew A. Tubelli, P. Bandopadhayay, Aviad Tsherniak, F. Vazquez, Bang Wong, Chet Birger, M. Ghandi, A. Thorner, Joshua A. Bittker, M. Meyerson, G. Getz, R. Beroukhim, T. Golub   +29 more
semanticscholar   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Chinese Expert Consensus on Second-line Treatment for Non-small Cell Lung Cancer with Negative Driver Gene Mutations

Chinese Journal of Lung Cancer
For advanced non-small cell lung cancer (NSCLC) patients with negative driver gene mutations, chemotherapy has always been the standard treatment option, and immune checkpoint inhibitors (ICIs) provide other treatment option for these patients.
Expert Committee on Non-small Cell Lung Cancer of the Chinese Society of Clinical Oncology
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source