Results 81 to 90 of about 2,753,395 (319)

Cancer as a Disease of the Cell

The Oncologist, 2022
This commentary highlights cases in which human-to-human transfers of cancers have occurred and what this could mean for a cure for cancer.
openaire   +2 more sources

Final Fate of Cancer Cells After Nuclear Genetic Material Damage

Zhongliu Fangzhi Yanjiu
Cancer cells refer to a group of malignant cells with strong division and proliferation abilities. Cancer cells rely on the unstable plunder of human nutrition to sustain the large amount of energy that they need for their own division and proliferation.
Lei WANG, Xiaomin XU, Jian WANG, Fangzheng MOU, Darong WEI   +4 more
doaj   +1 more source

Two novel Zn(II)-Li(I)-based and In(III)-based coordination polymers: crystal structures and anti-lung cancer activity

Main Group Metal Chemistry, 2018
In this study, two new metal-organic frameworks, namely, {(H2NMe2)[Zn3LiO(BTA)2](DMF)3}n (1, H3BTA=3,3′,3″-[1,3,5-benzenetriyltris(carbonylimino)] trisbenzoic acid) and {(Me2NH2)2[In2(TTA)2(FBA)2](DMF)3}n (2, H3TTA=4,4′-(((5-((4-(hydroxy-l2-methoxy ...
Meng Xian-Qing, Dong Xiao-Bin, Wang Hui, Tian Zheng-Yun   +3 more
doaj   +1 more source

Role of CTCF in the regulation of microRNA expression

Frontiers in Genetics, 2012
MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. MiRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as
Yoshimasa eSaito, Hidetsugu eSaito
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Cancer stem cells in esophageal squamous cell cancer.

Oncology letters, 2019
Cancer stem cells (CSCs) are hypothesized to govern the origin, progression, drug resistance, recurrence and metastasis of human cancer. CSCs have been identified in nearly all types of human cancer, including esophageal squamous cell cancer (ESCC). Four major methods are typically used to isolate or enrich CSCs, including: i) fluorescence-activated ...
Wu, Qian, Wu, Zhe, Bao, Cuiyu, Li, Wenjing, He, Hui, Sun, Yanling, Chen, Zimin, Zhang, Hao, Ning, Zhifeng   +8 more
openaire   +2 more sources

Consensus on Application of Third-generation EGFR-TKI in EGFR Mutated NSCLC 
(2022 Version)

Chinese Journal of Lung Cancer, 2022
Chinese Society of Clinical Oncology (CSCO) Non-small Cell Lung Cancer Committee, Anti-cancer Drug Safety Management Committee (ASMC)   +1 more
doaj   +1 more source

Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing

Frontiers in Bioscience-Landmark
Ageing comprises a cascade of processes that are inherent in all living creatures. There are fourteen general hallmarks of cellular ageing, the majority of which occur at a molecular level.
George Miloshev, Penyo Ivanov, Bela Vasileva, Milena Georgieva   +3 more
doaj   +1 more source