Results 81 to 90 of about 85,768 (307)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

ENFERMAGEM EM SAÚDE DA MULHER: RE-VISITANDO A PRODUÇÃO ACADÊMICA SOBRE O CÂNCER DE MAMA

Revista de Pesquisa Cuidado é Fundamental Online, 2010
Objetivos: identificar as produções acadêmicas de enfermagem na temática de câncer de mama oriundas da pós-graduação stricto sensu; quantificar as produções acadêmicas de enfermagem sobre câncer de mama relacionando-as com os programas de pós-graduação ...
Lazuli Reis Sá, Ivis Emília de Oliveira Souza   +1 more
doaj   +4 more sources

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

CÂNCER DE MAMA: A POSSIBILIDADE DA DETECÇÃO PRECOCE

Revista Uningá, 2014
Os elevados índices de incidência e mortalidade por câncer de mama no Brasil justificam a implementação de ações nacionais voltadas para a prevenção e o controle do câncer.
HENRIQUE O. LAUER BARTH, ADRIANA DE SANT’ ANA GASQUEZ   +1 more
doaj  

Uso de internet para evaluar el distrés psicológico en pacientes con cáncer de mama [PDF]

, 2014
Objective: The object of this study is to determine the prevalence of distress symptoms and coping strategy among a large sample of Spanish-speaking breast cancer patients recruited on-line. Methods: We designed a cross-sectional study with breast cancer
Díez, Anna, Estapé, Jordi, Estapé, Tania, Soria-Pastor, Sara   +3 more
core   +2 more sources

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Diagnóstico de câncer de mama: sentimentos, comportamentos e expectativas de mulheres

Revista Eletrônica de Enfermagem, 2005
O câncer de mama é a neoplasia maligna responsável pelo maior número de óbitos em mulheres no mundo, inclusive no Brasil. Considerando que a mulher vivencia situações singulares, após a descoberta da doença, que interessam à assistência de saúde.
Malena de Fátima Silva Regis, Sonia Mara Faria Simões   +1 more
doaj  

Fertilidade após cancro da mama : perspectivas [PDF]

, 2010
Dissertação de mestrado em Medicina (Ginecologia), apresentado à Faculdade de Medicina da Universidade de CoimbraOs progressos no diagnóstico e tratamento do cancro da mama associam-se a um diagnóstico cada vez mais precoce da doença e a um aumento da ...
Cotta, Catarina Aires Rebelo
core  

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source