Results 141 to 150 of about 60,470 (301)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Peut-on déterminer la prévalence d'une maladie en fonction de la fréquence de son nom sur le web ? Le cas du cancer au Japon [PDF]
, 2016 We wondered if there is a correlation between the frequency of the names of diseases on the web, and the prevalence of these diseases within the population who use this web.
Blin, Raoul
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Plans de soins de suivi normalisés et individualisés dédiés aux survivantes du cancer du sein : Évaluation du programme. [PDF]
Can Oncol Nurs J, 2021 Rutkowski N +5 more
europepmc +1 more source
L'implication des cellules de type cellules souches cancéreuses dans la résistance aux drogues du neuroblastome [PDF]
, 2011 Le neuroblastome (NB), tumeur spécifique de l'enfant, se situe au second rang en terme de¦fréquence des tumeurs solides dans la population pédiatrique (1).
Chevalier, N.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
[Acute congestive heart failure due to Bevacizumab in metastatic breast cancer: a case report]. [PDF]
Pan Afr Med J, 2022 Akimana G +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
De la médecine à la biomédecine : les multiples figures du patient [PDF]
, 2009 Ces dernières décennies, la médecine a connu une « scientificisation » accrue. Ce terme désigne deux phénomènes en partie liés. Le premier phénomène est l'émergence, de l'intérieur même de la profession médicale, de la médecine des preuves, plus connue ...
Rabeharisoa, Vololona
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source