Results 61 to 70 of about 287,041 (297)

Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

Frontiers in Immunology, 2020
Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments fail to increase overall survival.
Ece Canan Sayitoglu, Ece Canan Sayitoglu, Anna-Maria Georgoudaki, Anna-Maria Georgoudaki, Anna-Maria Georgoudaki, Michael Chrobok, Didem Ozkazanc, Benjamin J. Josey, Benjamin J. Josey, Muhammad Arif, Kim Kusser, Michelle Hartman, Tamara M. Chinn, Renee Potens, Cevriye Pamukcu, Robin Krueger, Cheng Zhang, Adil Mardinoglu, Adil Mardinoglu, Evren Alici, Harry Thomas Temple, Tolga Sutlu, Adil Doganay Duru, Adil Doganay Duru, Adil Doganay Duru   +24 more
doaj   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Immune Checkpoint Inhibition in Head and Neck Cancer

Frontiers in Oncology, 2018
Head and Neck Squamous Cell Carcinoma (HNSCC) is the 6th most common cancer globally and commonly presents with locally advanced disease, which has a recurrence rate of around 50% despite aggressive multi-modality treatment involving surgery ...
Martin David Forster, Michael-John Devlin   +1 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Moleculer nutritional immunology and cancer

Journal of Oncological Sciences, 2018
The immune system composed of cells that are sensitive to a series of surrounding factors and forming an integrated network. During the last decade a significant increase in the number of studies demonstrated that diet components released from adipocytes
Rüksan Çehreli
doaj  

Molecular Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolated from Egyptian Pediatric Cancer Patients Including a Strain with a Rare Gene-Combination of β-Lactamases

Infection and Drug Resistance, 2021
Dina Osama,1 Hadir El-Mahallawy,2 Mohamed Tarek Mansour,3 Abdelgawad Hashem,4,5 Ahmed S Attia4 1Department of Microbiology and Immunology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Cairo, Egypt; 2Department of Clinical ...
Osama D, El-Mahallawy H, Mansour MT, Hashem A, Attia AS   +4 more
doaj  

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

11th Immunotherapy of Cancer conference (ITOC): A meeting report

Human Vaccines & Immunotherapeutics
The Immunotherapy of Cancer (ITOC) meeting is an international conference providing a platform for immuno-oncologists worldwide to present and discuss their research and newest findings. Being held in Munich annually, the 11th edition took place in April
Stefanos Michaelides, Viktoria Hartmann, Volkmar Nüssler, Christoph Zielinski, Michael von Bergwelt-Baildon, Sebastian Kobold   +5 more
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source