Results 121 to 130 of about 7,013,774 (312)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Structural basis of human 20S proteasome biogenesis

Nature Communications
New proteasomes are produced to accommodate increases in cellular catabolic demand and prevent the accumulation of cytotoxic proteins. Formation of the proteasomal 20S core complex relies on the function of the five chaperones PAC1-4 and POMP.
Hanxiao Zhang, Chenyu Zhou, Zarith Mohammad, Jianhua Zhao   +3 more
doaj   +1 more source

Molecular architecture of a cylindrical self-assembly at human centrosomes

Nature Communications, 2019
The centrosome is a membraneless organelle composed of two centrioles and an amorphous pericentriolar material but the overall centrosome organizations remains unknown.
Tae-Sung Kim, Liang Zhang, Jong Il Ahn, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, Yun-Xing Wang, Bo Yeon Kim, Jung-Eun Park, Kyung S. Lee   +13 more
doaj   +1 more source

Wnt Signaling in Cancer Metabolism and Immunity

Cancers, 2019
The Wingless (Wnt)/β-catenin pathway has long been associated with tumorigenesis, tumor plasticity, and tumor-initiating cells called cancer stem cells (CSCs).
S. El-Sahli, Ying Xie, Lisheng Wang, Sheng Liu   +3 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cancer can be suppressed by alkalizing the tumor microenvironment: the effectiveness of “alkalization therapy” in cancer treatment

Oncologie
The abnormal metabolism of cancer cells, referred to as the Warburg effect, creates acidic tumor microenvironments (TME) that can contribute to treatment resistance and cancer progression.
Kachi Shion, Hamaguchi Reo, Narui Ryoko, Morikawa Hiromasa, Okamoto Toshihiro, Wada Hiromi   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Causal association between oral microbiota and oral cancer: a mendelian randomization study

Scientific Reports
Many studies have reported an association between oral microbiota and oral cancer (OC). Yet, the causal relationship between oral microbiota and OC remains undetermined.
Zhu Wu, Qiu Peng, Zongyao Ren, Xuemeng Xu, Xianjie Jiang, Wenjuan Yang, Yaqian Han, Linda Oyang, Jinguan Lin, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Qianjin Liao, Yujuan Zhou   +13 more
doaj   +1 more source

Cancer‐associated fibroblasts modify lung cancer metabolism involving ROS and TGF‐&bgr; signaling

Free Radical Biology & Medicine, 2019
Lung cancer is a major public health problem due to its high incidence and mortality rate. The altered metabolism in lung cancer is key for the diagnosis and has implications on both, the prognosis and the response to treatments.
A. Cruz-Bermúdez, R. Laza-Briviesca, R. J. Vicente-Blanco, Aránzazu García-Grande, M. Coronado, S. Laine-Menéndez, C. Alfaro, J. C. Sanchez, Fernando Franco, V. Calvo, A. Romero, P. Martín-Acosta, C. Salas, J. García, M. Provencio   +14 more
semanticscholar   +1 more source