Results 121 to 130 of about 4,807,572 (318)

Molecular architecture of a cylindrical self-assembly at human centrosomes

Nature Communications, 2019
The centrosome is a membraneless organelle composed of two centrioles and an amorphous pericentriolar material but the overall centrosome organizations remains unknown.
Tae-Sung Kim, Liang Zhang, Jong Il Ahn, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, Yun-Xing Wang, Bo Yeon Kim, Jung-Eun Park, Kyung S. Lee   +13 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Structural basis of human 20S proteasome biogenesis

Nature Communications
New proteasomes are produced to accommodate increases in cellular catabolic demand and prevent the accumulation of cytotoxic proteins. Formation of the proteasomal 20S core complex relies on the function of the five chaperones PAC1-4 and POMP.
Hanxiao Zhang, Chenyu Zhou, Zarith Mohammad, Jianhua Zhao   +3 more
doaj   +1 more source

Metabolic effects of cancer

Journal of British Surgery, 1990
Abstract The potential causes of deranged metabolism in cancer are discussed with emphasis on changes in energy metabolism of glucose, fat and protein. The implications of these changes for the treatment of cachexia are then considered.
R G, Douglas, J H, Shaw
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Causal association between oral microbiota and oral cancer: a mendelian randomization study

Scientific Reports
Many studies have reported an association between oral microbiota and oral cancer (OC). Yet, the causal relationship between oral microbiota and OC remains undetermined.
Zhu Wu, Qiu Peng, Zongyao Ren, Xuemeng Xu, Xianjie Jiang, Wenjuan Yang, Yaqian Han, Linda Oyang, Jinguan Lin, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Qianjin Liao, Yujuan Zhou   +13 more
doaj   +1 more source

Cancer Trends: Cancer of the liver and biliary tract

, 2010
Liver cancer consists of two main types—hepatocellular carcinoma (HCC) which accounts for about 60% of cases, and intrahepatic bile duct cholangiocarcinoma (ICC), which accounts for about 20%. The liver is one of the less common cancer sites, about 0.
National Cancer Registry Ireland (NCRI)
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dietary patterns among Afghan adults and their associations with overweight and obesity: a cross-sectional study in Kandahar, Afghanistan

BMC Public Health
Background Although obesity is on the rise in Afghanistan, to date no studies have investigated associations with diet and dietary patterns. Therefore, the present study aimed to assess the different dietary patterns consumed among Afghan adults living ...
Mohammad Sediq Sahrai, Laure Dossus, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Abdul Wahed Wasiq, Marc J. Gunter, Inge Huybrechts   +7 more
doaj   +1 more source

Methylglyoxal-Derived Nucleoside Adducts Drive Vascular Dysfunction in a RAGE-Dependent Manner

Antioxidants
Diabetic kidney disease (DKD) is a leading cause of death in patients with diabetes. An early precursor to DKD is endothelial cell dysfunction (ECD), which often precedes and exacerbates vascular disease progression.
Seigmund Wai Tsuen Lai, Supriyo Bhattacharya, Edwin De Jesus Lopez Gonzalez, Sarah C. Shuck   +3 more
doaj   +1 more source