Results 181 to 190 of about 4,807,572 (318)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Lactate, Carbohydrate Restriction, and Cancer Metabolism. [PDF]

Med Princ Pract
Luqmani YA.
europepmc   +1 more source

Cancer Trends: Hodgkin’s lymphoma

, 2013
An average of 101 cases of Hodgkin’s lymphoma (HL) was diagnosed per year in Ireland between 1994 and 2011, equating to an incidence rate of 2.5 cases per 100,000 per year (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics

Although Otto Warburg may be right about the role of glycolysis versus OXPHOS in cancer metabolism, it remains unclear whether an altered metabolism is causative or correlative and is the main driver or a mere passenger in the pathogenesis of cancer ...
Timothy Langford, Sunny R. Singh, Ping-Ching Hsu, Jim Z. Chen, Sanjay Maraboyina, Neriman Gokden, Shi-Ming Tu   +6 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Targeting the cancer metabolism-immunity interface: update and perspectives. [PDF]

Exp Hematol Oncol
Di Carlo E.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Ferroptosis as an approach to leverage cancer metabolism. [PDF]

Trends Cell Biol
Jin J, Hu J, Li M, Gu W, Jiang X, Stockwell BR.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Oncometabolites in Cancer Metabolism: Mechanistic Insights and Biomarker Potential- A Narrative Review. [PDF]

Health Sci Rep
Khatun MM, Sarker MA, Podder MK, Biswas MS, Hasan MM, Tamannaa Z, Hossain MN, Badhon RS, Akter MA.   +8 more
europepmc   +1 more source