Results 171 to 180 of about 897,136 (317)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Evolutionary characterization of lung cancer metastasis. [PDF]

Nature
Hessey S, Bunkum A, Huebner A, Haase K, Grigoriadis K, Naceur-Lombardelli C, Liu WK, Harrigan CF, Grieco C, Marinelli D, Ding B, Martínez-Ruiz C, Pawlik P, Hill MS, Lucas O, Richard C, Pich O, Thol K, Karasaki T, Ward S, Athanasopoulou F, Sivakumar M, Veeriah S, Toncheva A, Rowan AJ, Prymas P, Bridger H, Mitchison M, Borg E, Falzon M, Proctor I, Mahadeva U, Green A, Forster MD, Benafif S, Ahmad T, Lee SM, Papadatos-Pastos D, Naidu B, Langman G, Krebs MG, Oliveira P, Blackhall FH, Summers Y, Weaver J, Le Quesne J, Thomas A, Richards C, Fennell DA, Jogai S, Cave J, Roxburgh P, Fraser S, Kirk A, Blyth KG, Russell P, Hiley CT, Hackshaw A, TRACERx Consortium, TRACERx EVO Consortium, PEACE consortium, Moore DA, Zaccaria S, McGranahan N, Swanton C, Jamal-Hanjani M.   +65 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Epigenetic regulation in cancer metastasis. [PDF]

Discov Oncol
Sun Z, Wu Y, Zong X, Liu H, Sun X, Wang S, Liu J.   +6 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Breast cancer metastasis to the colon mimicking primary colorectal carcinoma. [PDF]

EJNMMI Rep
Liu Q, Gao J, Yang H, Chen X, He Y.
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Special Issue "Editorial Board Members' Collection Series: Cancer Metastasis". [PDF]

Int J Mol Sci
Cabañas C.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source