Results 161 to 170 of about 970,429 (266)

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Association between meat consumption and cancer mortality in Korean adults. [PDF]

Front Nutr
Ryou IS, Cho HJ, Sohn YJ, Lee JE, Park M.   +4 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Social mobility and cancer mortality in Central and Eastern Europe: a multicohort study. [PDF]

Eur J Public Health
Pan Y, Pikhart H, Pajak A, Tamosiunas A, Court T, Kozela M, Peasey A, Stefler D, Bobak M.   +8 more
europepmc   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Correction for 'Impact of loneliness on cancer mortality: a systematic review and meta-analysis'. [PDF]

BMJ Oncol
europepmc   +1 more source

Radiation Exposure and Cancer Mortality in Populations Living Around the Semipalatinsk Nuclear Test Site in Kazakhstan. [PDF]

Int J Environ Res Public Health
Dyussupov A, Kissina R, Chaizhunussova N, Shabdarbayeva D, Orekhov A, Smailova Z, Massabayeva M, Baibussinova A, Lipikhina A, Brait Y, Klivenko A, Apbassova S, Batenova G, Lepesbayev M, Kozhanova S, Izdenov A, Dosmagambetova R, Pivina L.   +17 more
europepmc   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Colorectal Cancer Mortality Following an Organized Fecal Immunochemical Test-Based Screening Program.

JAMA Netw Open
Bujanda L, Val B, Portillo Villares I, Idigoras-Rubio I, Banales JM, Gutierrez-Stampa MA, Lopez de Munain A, Audicana C, Calleja O, Cubiella J, Izquierdo-Sanchez L.   +10 more
europepmc   +1 more source