Results 61 to 70 of about 4,194,562 (264)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

County-level social, preventive care, and behavioral correlates of colorectal cancer mortality in the United States: a nationwide ecological analysis

Frontiers in Oncology
BackgroundGeographic disparities in colorectal cancer (CRC) outcomes remain substantial across U.S. counties. Associations of social conditions, preventive care, behavioral risk environments, and rurality with CRC mortality remain incompletely ...
Kaide Xia, Li Luo, Chengdu Fan, Hexuan Zhang, Xiuju Yang, Chaohuang Lin   +5 more
doaj   +1 more source

Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins. [PDF]

, 2004
AIMS: To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins. METHODS: Phenoxy herbicide producers (n = 1025) and sprayers (n = 703) were followed up from 1 January 1969 and 1 January 1973 respectively to 31 ...
McLean, D, Boffetta, P, 't Mannetje, A, Colin, D, Pearce, N., Cheng, S., Colin, D., Cheng, S, Pearce, N, 'T Mannetje, A., McLean, D., Boffetta, P., A 't Mannetje   +12 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Global Burden, Projection, and Inequalities Analysis of Cancer Attributable to Occupational Carcinogen Exposure in Individuals Aged Over 40 Years

Cancer Medicine
Background In this study, we investigated the global burden, projection, and inequalities of cancer attributable to occupational carcinogen exposure in individuals aged over 40 years.
Nanxi Hu, Hui Li, Kaili Yu, Yang Yu, Xiaohua Wu, Xinyi Huang, Hongtao Lin, Shuqing Zou, Jinluan Li   +8 more
doaj   +1 more source

Dietary spermidine intake is not associated with prostate cancer incidence or prostate cancer-specific mortality: findings from the prostate, lung, colorectal, and ovarian cancer screening trial

Frontiers in Nutrition
BackgroundThe role of dietary spermidine in prostate cancer outcomes remains unclear. We examined associations between spermidine intake and prostate cancer incidence, all-cause mortality, and prostate cancer-specific mortality in a large prospective ...
Guilin Wang, Guilin Wang, Jiayi Lin, Zhifeng Lin, Jinhui Jian, Jiongxuan Xu, Jie Xie, Shun Liu, Qingquan Chen, Dewen Zhong   +9 more
doaj   +1 more source

Association between rapid renal function deterioration and cancer mortality in the elderly: A retrospective cohort study

Cancer Medicine, 2023
Background Kidney function is associated with clinical outcomes in patients with cancer. Objectives This study aimed to assess the association between kidney function decline and cancer‐related mortality among community‐dwelling elderly individuals ...
I‐Ching Kuo, Yi‐Chi Chu, Yen‐Hsu Chen, Ta‐Chien Chan   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Urinary Lead Concentration Is an Independent Predictor of Cancer Mortality in the U.S. General Population

Frontiers in Oncology, 2018
Lead is a ubiquitous pollutant that constitutes an environmental hazard worldwide. Although lead has been known as a carcinogenic factor in animal models, its role in human carcinogenesis is still a topic of debate with limited epidemiological evidence ...
Sen Li, Sen Li, Jiaxin Wang, Biao Zhang, Yuan Liu, Tao Lu, Yuanyuan Shi, Guangliang Shan, Ling Dong   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source