Results 81 to 90 of about 1,686,195 (359)

Effect of allogeneic intraoperative blood transfusion on survival in patients treated with radical cystectomy for nonmetastatic bladder cancer: Results from a single high-volume institution [PDF]

, 2015
Transfusion has been related to poor survival after surgery in several cancers. Recently, timing of transfusion has been proposed as crucial in the determination of poor survival expectanies after surgery, in fact, intra- operative but not postoperative ...
Briganti, Alberto, Capogrosso, Paolo, Colombo, Renzo, Cucchiara, Vito, Damiano, Rocco, Dell'Oglio, Paolo, Gandaglia, Giorgio, Luzzago, Stefano, Montorsi, Francesco, Moschini, Marco, Salonia, Andrea, Zattoni, Fabio   +11 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels based on the Global Burden of Disease database

Frontiers in Nutrition
ObjectiveTo analyze temporal trends of diet-attributable cancer mortality in China (1990–2021), compare patterns between China and regions with varying development levels, and explore gender-specific characteristics to inform targeted prevention ...
Chunxiu Zhao, Qian Ruan, Bingbing Xiang, Xuehe Zhang, Pingliang Yang, Shun Wang   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Association between oxidative balance score and all-cause and cancer-specific mortality among cancer survivors

Frontiers in Immunology
BackgroundThe Oxidative Balance Score (OBS) represents a novel metric for assessing systemic oxidative stress, where elevated scores reflect increased antioxidant exposure.
Qingmei Gao, Xinfang Zhu, Mengke Chen, Rong Xia, Qi Zhang   +4 more
doaj   +1 more source

Relationship between hospital volume and short-term outcomes: A nationwide population-based study including 75,280 rectal cancer surgical procedures [PDF]

, 2018
There is growing interest on the potential relationship between hospital volume (HV) and outcomes as it might justify the centralization of care for rectal cancer surgery. From the National Italian Hospital Discharge Dataset, data on 75,280 rectal cancer
Barina, Andrea, Bergamo, Francesca, Boso, Caterina, Corti, Maria Chiara, Frambach, Patrick, Gennaro, Nicola, Marchegiani, Francesco, Maretto, Isacco, Perin, Alessandro, Pucciarelli, Salvatore, Rugge, Massimo, Urso, Emanuele Damiano Luca, Zorzi, Manuel, Zuin, Matteo   +13 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Beyond self-reports: serum cotinine reveals sex-and age-related differences of smoking on all-cause and disease-specific mortality

Frontiers in Public Health
BackgroundIt is well-known that sex and age play critical roles in smoking-related diseases and mortality. However, quantification of the extent of smoking requires self-reports in these studies, which may yield only partially accurate results.
Qi Jiang, Liu Junjun, Xiaochuan Wang, Li Luo, Gaoyan He, Xiaojuan Wu, Qian Min, Ying Long, Wang Wenjun, Tao Zhu, Yu Yao   +10 more
doaj   +1 more source

Weight change and 15 year mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study. [PDF]

, 2018
Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased mortality risk. We examined changes

core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source