Results 91 to 100 of about 4,194,562 (264)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cohort fertility patterns and breast cancer mortality among U.S. women, 1948-2003 [PDF]

Epidemiological research has shown that women who have early and numerous births have reduced risks of being diagnosed with breast cancer. We use U.S.
Patrick M. Krueger, Samuel Preston
core  

Estimation and projection of the national profile of cancer mortality in China: 1991-2005. [PDF]

, 2004
There are no national-level data on cancer mortality in China since two surveys in 1973-1975 and 1990-1992 (a 10% sample), but ongoing surveillance systems, based on nonrandom selected populations, give an indication as to the trends for major cancers ...
Li, LD, F Bray, Bray, F, L Yang, Yang, L, Parkin, DM, Y D Chen, Yang, Ling, Chen, YD, D M Parkin, L D Li   +10 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Increasing survival disparity between children, adolescents, and young adults with osteosarcoma or Ewing sarcoma of bone from 1990 to 2024: a population-based cohort study

Acta Oncologica
Background and purpose: Bone sarcomas are important contributors to early-life cancer mortality and morbidity. Optimisation of treatment regimens has improved survival, but the survival disparity between children, adolescents and young adults has ...
Daniel Thor Halberg Dybdal, Klaus Rostgaard, Henrik Hjalgrim, Ninna Aggerholm-Pedersen, Niels Junker, Thomas Baad-Hansen, Pernille Wendtland Edslev, Eva Kristine Ruud Kjær, Akmal Safwat, Michael Mørk Petersen, Lisa Lyngsie Hjalgrim   +10 more
doaj   +1 more source

Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD Trial) [PDF]

, 2012
Context: Vitamin D or calcium supplementation may have effects on vascular disease and cancer. Objective: Our objective was to investigate whether vitamin D or calcium supplementation affects mortality, vascular disease, and cancer in older people ...
McDonald, AM, Campbell, MK, Torgerson, DJ, Marsh, D., RECORD Trial Group, Pant, Puspa R., Grant, Adrian, Adrian M. Grant, Wallace, W Angus., Wallace, W. Angus, MacLennan, GS, Eastell, R., Campbell, Marion K., Robinson, C. Michael, Cyrus Cooper, David J. Torgerson, Maclennan, Graeme S., Wallace, WA, McPherson, GC, Avenell, A, null null, Grant, AM, Francis, Roger M., Graeme S. MacLennan, William J. Gillespie, Jenkinson, David, Khaw, K. T., Francis, RM, McDonald, GM, Pant, PR, C. Michael Robinson, Cooper, Cyrus, Alison M. McDonald, Roger M. Francis, Jenkinson, DJ, McDonald, Alison M., Jenkinson, David J., Frazer H. Anderson, W. Angus Wallace, Torgerson, David J., David J. Jenkinson, Robinson, CM, Puspa R. Pant, Grant, Adrian M., Anderson, FH, Marion K. Campbell, Pant, Puspa Raj, Anderson, Frazer H., Alison Avenell, Cooper, C, Avenell, Alison, McPherson, Gladys C., Gillespie, William J., Gladys C. McPherson, Gillespie, WJ   +54 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Avoidable Cancer Mortality in Germany Since Reunification: Regional Variation and Sex Differences

Frontiers in Public Health, 2019
Background: Regional comparisons of cancer-related mortality in Germany are traditionally focused on disparities between East and West Germany. Recent improvements in all-cause and cancer-related mortality show a diverse regional pattern beyond the known
Ronny Westerman, Michael Mühlichen
doaj   +1 more source

REMARKS ON THE MORTALITY FROM CANCER. [PDF]

The Lancet, 1898
n ...
openaire   +1 more source

Forecasting age-related changes in breast cancer mortality among white and black US women: A functional approach [PDF]

The disparity in breast cancer mortality rates among white and black US women is widening with higher mortality rates among black women. We apply functional time series models on age-specific breast cancer mortality rates for each group of women, and ...
Farah Yasmeen, Rob J Hyndman, Bircan Erbas   +2 more
core