Results 191 to 200 of about 6,638,408 (368)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Evaluating buprenorphine to treat cancer pain: a systematic review protocol. [PDF]

Syst Rev
Khateeb R, Powell V, Rosenberg J, Rose L, Sheehan K, Mackey C, Papaioannou P, Silveira M.   +7 more
europepmc   +1 more source

Mindful breathing for cancer pain: efficacy of a single 20-minute session – a randomised controlled study [PDF]

Tan Seng Beng, Chee-Shee Chai, Diana-Leh-Ching Ng, Sheriza Izwa Zainuddin, David Paul Capelle, Chee Loong Lam, Chui Munn Ang, Win Lin Chai, Nik Natasha Nik Ishak, Yu Xiang Ong, Ying Xi Ngu   +10 more
openalex   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

The 3P-CP model: Expanding our conceptualization of cancer pain. [PDF]

Cancer
Azizoddin DR, Zhao J, Somers TJ, Taylor SE, Winger JG, Dorsey SG, Orris S, Nasta A, Schenker Y, Merlin JS, Jim HSL, Schreiber KL, Bulls HW.   +12 more
europepmc   +1 more source

Opioids combined with antidepressants or antiepileptic drugs for cancer pain: Systematic review and meta-analysis

Palliative Medicine, 2018
C. Kane, M. Mulvey, Sophie Wright, C. Craigs, Judy M. Wright, M. Bennett   +5 more
semanticscholar   +1 more source

Retrospective Analysis Based on Clinical Experience of Tapentadol in Cancer Pain Management

, 2016
Tomoe Fukunaga, Tatsuo Kamikawa, Masahiro Senta, Shin‐ichi Ishikawa   +3 more
openalex   +2 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Verapamil and venlafaxine combined as an effective and well-tolerated adjunct for cancer pain management. [PDF]

Am J Transl Res
Deng Q, Li N, Wang Y.
europepmc   +1 more source

Decreasing Pain Intensity in Adult Patients With Cancer Through Music Therapy: A Complementary Non-Pharmacological Approach [PDF]

L. Montoya, Dorothie Durosier Mertilus
openalex   +1 more source