Results 201 to 210 of about 6,638,408 (368)

Cannabis use and non-cancer chronic pain [PDF]

, 2018
Alex Bekker
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Right Hemispheric Neuronal Dysfunction in Cancer Pain: A Resting-State fMRI Exploratory Study. [PDF]

J Pain Res
Xu D, Liu Z, Wu Z, Zhang Y, He Y.
europepmc   +1 more source

Ketamine for chronic non‐cancer pain: A meta‐analysis and trial sequential analysis of randomized controlled trials

European Journal of Pain, 2018
D. Michelet, C. Brasher, A.-L. Horlin, M. Bellon, F. Julien-Marsollier, T. Vacher, S. Pontone, S. Dahmani, S. Dahmani   +8 more
semanticscholar   +1 more source

The prescribing of opioids for chronic non-cancer pain in the menopausal and postmenopausal population: a drug utilisation study in the UK [PDF]

Emma Tillyer, Yogini Jani, Wei Li, Ruth Brauer   +3 more
openalex   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Multidisciplinary management of persistent severe cancer pain: a collaborative European approach. [PDF]

Support Care Cancer
Dupoiron D, Padilla ML, Iorfida M, Falcon A, Brown MRD, Perruchoud C, Zuidema X, Guardamagna V, Tornero C, Hoefing C, Bagchi S, Van Keulen D, Kortbaoui R, Macarulla T, Di Palma M.   +14 more
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Cancer pain: molecular mechanisms and management. [PDF]

Mol Biomed
Wang WL, Hao YH, Pang X, Tang YL.
europepmc   +1 more source

Opioids for chronic non-cancer pain in children and adolescents.

Cochrane Database of Systematic Reviews, 2017
Tess E. Cooper, E. Fisher, Andrew L Gray, E. Krane, N. Sethna, M. V. van Tilburg, B. Zernikow, P. Wiffen   +7 more
semanticscholar   +1 more source