Results 41 to 50 of about 1,102,828 (315)

Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model [PDF]

, 2014
Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not solved completely.
Ichikawa, Hiroyuki, Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morimatsu, Hiroshi, Muto, Noriko, Obata, Norihiko, Omiya, Hiroki, Sato, Tadasu, Taniguchi, Arata, Tomotsuka, Naoto   +12 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Ultrasound-guided suprainguinal fascia iliaca block versus lumbar erector spinae block for oncologic thigh surgery

PAIN Reports
. Introduction:. Effective pain management is essential for patients undergoing limb-sparing procedures as well as amputation in patients with cancer. Objectives:.
Ahmed Salah Abdelgalil, Hamed Sayed Ashour, Ayman Sharawy Abdelrahman, Ahmed Fahmy Ahmed, Fatma Hanafi Mahmoud, Mohamed El Sayed Hassan, Khaled Ali El Samahy, Sayed Mahmoud Abed   +7 more
doaj   +1 more source

Chemical Neurolysis of the Inferior Hypogastric Plexus for the Treatment of Cancer-Related Pelvic and Perineal Pain

Pain Research and Management, 2013
BACKGROUND: Various interventions, including the superior hypogastric plexus block and ganglion impar block, are commonly used for the treatment of pelvic or perineal pain caused by cancer.
Sahar Abd-Elbaky Mohamed, Doaa Gomaa Ahmed, Mohamad Farouk Mohamad   +2 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Methadone Conversion Using a 3-Day Switch Strategy in Patients with Cancer on High-Dose Opioids: A Retrospective Study

Pain and Therapy
Introduction Methadone has shown effectiveness in pain control in patients with cancer who are intolerant to other opioids in China. However, the optimal strategy for methadone conversion from previous high doses of opioids in refractory cancer pain ...
Lei Lei, Qinfei Zhou, Xi Liu, Guanai Bao, Haiying Ding, Qunfang Ding, Liyan Gong   +6 more
doaj   +1 more source

Evaluation of dexmedetomidine as a sole agent in sedation of cancer patients undergoing radiological interventional procedures

Egyptian Journal of Anaesthesia, 2017
Background: Previous studies have shown that dexmedetomidine has proven effectiveness as sedative in many outpatient settings and several reports are now available documenting its success for sedation of both non-invasive and invasive procedures ...
Ayat Abdelfattah Hassan, Wafaa Taha Salem, Maie Kamaleldein Helaly, Ghada M. Bashandy, Reda Tabashy, May Abdelfattah   +5 more
doaj   +1 more source

Carbon Dioxide Retention after Non-Cardiac Surgery in a Patient with Cor Pulmonale [PDF]

Journal of Acute Care Surgery, 2018
Regional anesthesia is generally recommended over general anesthesia for non-cardiac surgeries in patients with severepulmonary hypertension (PH) caused by pulmonary disease.
Tak Kyu Oh, Hyeyeon Cho, Dae-Soon Cho
doaj   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided intermediate cervical plexus block for thyroidectomy surgery: randomized controlled study

BMC Anesthesiology
Background One important aspect of a successful thyroidectomy recovery is the level of pain postoperatively. This research aimed to determine the effectiveness of an ultrasound-guided intermediate cervical plexus block (CPB) for thyroidectomy with ...
Mamdouh Mahmoud Mostafa, Reham M. Gamal, Aya M. Ahmed Baiomy, Mohamed Elsayed Hassan, Jehan Mohamed Kamal, Thabet TS, Tamer A. Kotb, Mai M. Elrawas   +7 more
doaj   +1 more source