Results 71 to 80 of about 6,321,039 (371)

A Study Protocol for an Instrumental Variables Analysis of the Comparative Effectiveness of two Prostate Cancer Drugs [PDF]

arXiv, 2021
This paper presents a protocol, or design, for the analysis of a comparative effectiveness evaluation of abiraterone acetate against enzalutamide, two drugs given to prostate cancer patients. The design explicitly make use of differences in prescription practices across 21 Swedish county councils for the estimation of the two drugs comparative ...
arxiv  

Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype

Molecular Pain, 2018
Bone cancer pain remains a major challenge in patients with primary or metastatic bone cancer due to a lack of understanding the mechanisms. Previous studies have revealed the two distinct functional polarization states of microglia (classically ...
Wenwen Huo, Ying Zhang, Yue Liu, Yishan Lei, Rao Sun, Wei Zhang, Yulin Huang, Yan-ting Mao, Chenchen Wang, Zhengliang Ma, X. Gu   +10 more
semanticscholar   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided intermediate cervical plexus block for thyroidectomy surgery: randomized controlled study

BMC Anesthesiology
Background One important aspect of a successful thyroidectomy recovery is the level of pain postoperatively. This research aimed to determine the effectiveness of an ultrasound-guided intermediate cervical plexus block (CPB) for thyroidectomy with ...
Mamdouh Mahmoud Mostafa, Reham M. Gamal, Aya M. Ahmed Baiomy, Mohamed Elsayed Hassan, Jehan Mohamed Kamal, Thabet TS, Tamer A. Kotb, Mai M. Elrawas   +7 more
doaj   +1 more source

Evaluation of unilateral ultrasound guided paravertebral block for perioperative analgesia in cancer patients undergoing lower limb sparing surgeries: A prospective randomized controlled trial

Egyptian Journal of Anaesthesia, 2021
Background Formerly management of malignant tumors of lower limb was mainly through amputation. After advancement in neoadjuvant chemo-radiotherapy, saving the limb through lower limb-sparing surgery became the main line for management.
Yasmen F. Mohamed, Sayed M. Abed, Tamer M. Khair, Ahmed Abdalla Mohamed, Enas Samir, Walaa Y. Elsabeeny   +5 more
doaj   +1 more source

Statistical Applications in Pain Management: A Review [PDF]

arXiv, 2023
Chronic pain is a widespread and debilitating condition that affects millions of individuals worldwide. Recent research has unveiled a connection between chronic pain and epigenetic processes, shedding light on the complex interplay between genetics, environment, and pain perception.
arxiv  

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model [PDF]

Maqboul A, Elsadek B. (2018) Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model. PeerJ 6:e4622 https://doi.org/10.7717/peerj.4622, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient receptor potential vanilloid 1 (TRPV1) and of transient receptor potential vanilloid 4 ...
arxiv   +1 more source

Ketamine for chronic non‐cancer pain: A meta‐analysis and trial sequential analysis of randomized controlled trials

European Journal of Pain, 2018
Ketamine has been suggested to be efficient in relieving chronic pain. However, there is inconsistency across studies investigating the effect of ketamine for chronic pain management. We aimed to perform a meta‐analysis in order to assess the efficacy of
D. Michelet, C. Brasher, A.-L. Horlin, M. Bellon, F. Julien-Marsollier, T. Vacher, S. Pontone, S. Dahmani, S. Dahmani   +8 more
semanticscholar   +1 more source

Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.

JAMA Oncology, 2021
Importance The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain.
J. Mao, Kevin T. Liou, R. Baser, T. Bao, K. Panageas, S. Romero, Q. Li, R. Gallagher, P. Kantoff   +8 more
semanticscholar   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source