Results 141 to 150 of about 11,408,388 (316)

Commentary: MSH3 homology and potential recombination link to SARS-CoV-2 furin cleavage site

Frontiers in Virology, 2022
Yseulys Dubuy, Hugo Lachuer
doaj   +1 more source

Patients’ perceptions of the announcement of cancer diagnosis in Morocco “Cancer patients cases treated in the Fez-Meknes Region”

Journal of Education and Health Promotion
BACKGROUND: The announcement of a cancer diagnosis represents a real turning point, significantly and pessimistically changing the patient’s vision of his future. The task of the healthcare professional in communicating bad news is complex.
Oussama Rharib, Radouane Saadi, Aziz Mengad, Merouane Ertel, Younes Bouferma, Khadija Saka, Mohammed Ababou   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spiritual Well-being in Cancer Patients who Undergo Chemotherapy [PDF]

Objective: Spiritual well-being harmonizes several dimensions of human's life and is essential for coping with diseases. Chronic illnesses such as cancer cause crisis in physical, psychological and spiritual dimensions of ones life.
حبیبی, عقیل, سوادپور, محمدتقی   +1 more
core  

Strategies to Increase Vaccinations in Adult Cancer Patients: A Systematic Review

Vaccines
Background/Objectives: Although vaccinations are a priority for patients with cancer, achieving high coverage remains challenging. Evidence on effective strategies in oncology settings is still limited.
Giuseppina Lo Moro, Federica Golzio, Sara Claudia Calabrese, Giacomo Scaioli, Alessandro Basile, Roberta Siliquini, Fabrizio Bert   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cancer patients' care at the end of life in a critical care environment: perspectives of families, patients and practitioners [PDF]

Innovations in cancer care requiring intensive support, and improved cancer patient survival in and out of critical care, have led to greater numbers of cancer patients than ever accessing critical care.
Pattison, Natalie
core  

Efficacy and safety of the integrated puncture method vs. the conventional puncture method in Peripherally Inserted Central Catheter placement for cancer patients

Frontiers in Surgery
ObjectiveThis study aims to assess the efficacy and safety of the integrated puncture method compared to the conventional puncture method in cancer patients undergoing PICC placement.MethodsThe retrospective analysis included 224 cancer patients who ...
Xinpeng Wang, Yong Yang, Yuanyuan Zheng, Jie Chen, Yanfen Shen   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source