Results 101 to 110 of about 1,454,075 (309)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Lifetime risk of developing and dying from cancer in Henan Province, China: current status, temporal trends, and disparities

Journal of the National Cancer Center
Objective: To understand the current status and changing trends in the lifetime risk of residents in Henan Province, China to develop and die from cancer.
Qiong Chen, Shuzheng Liu, Yin Liu, Hongwei Liu, Hong Wang, Lanwei Guo, Huifang Xu, Xiaoli Guo, Xiaoyang Wang, Ruihua Kang, Liyang Zheng, Shaokai Zhang   +11 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Corrigendum: Construction and Validation of a Lung Cancer Risk Prediction Model for Non-Smokers in China

Frontiers in Oncology, 2022
Lan-Wei Guo, Zhang-Yan Lyu, Qing-Cheng Meng, Li-Yang Zheng, Qiong Chen, Yin Liu, Hui-Fang Xu, Rui-Hua Kang, Lu-Yao Zhang, Xiao-Qin Cao, Shu-Zheng Liu, Xi-Bin Sun, Jian-Gong Zhang, Shao-Kai Zhang   +13 more
doaj   +1 more source

Suicide risk transition and cumulative incidence post-cancer diagnosis: retrospective cohort study utilizing population-based cancer registry in Japan

BMC Cancer
Background Suicide risk in cancer patients peaks early post-diagnosis; however, detailed studies on its changes are scarce. We analyzed population-based cancer registry data to identify trends in suicide risk and incidence following diagnosis among ...
Kaname Watanabe, Sho Nakamura, Choy-Lye Chei, Hiroto Narimatsu   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Nutrition and Cancer Prevention

International Journal of Immunopathology and Pharmacology, 2012
Cancer cells invade surrounding tissues and metastasize to distant sites. Diet high in fat is a strong link to, and perhaps causes, a high incidence of tumours. Trans-fatty acid might impair the function and it could be involved in the development of cancer. Cholesterol is also strongly suspected to be involved in the development of tumours, therefore
TETE', Stefano, NICOLETTI, Mauro, Saggini A, Maccauro G, Rosati M, CONTI, FIORELLA, CIANCHETTI, Ettore, TRIPODI, Domenico, TONIATO, ELENA, FULCHERI, Mario, SALINI, VINCENZO, Caraffa A, Antinolfi P, Frydas S, Pandolfi F, CONTI, Pio, Potalivo G, Theoharides TC   +17 more
openaire   +5 more sources

Chromatin Laser Imaging Reveals Abnormal Nuclear Changes for Early Cancer Detection

, 2018
We developed and applied rapid scanning laser-emission microscopy to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors.
Aslam, Muhammad Nadeem, Bergin, Ingrid, Chen, Grace, Chen, Qiushu, Chen, Yu-Cheng, Fan, Xudong, Tan, Xiaotain   +6 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Biomarkers of lipid metabolism in gastric cancer: a case control study

BMC Cancer
Background The aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer. Methods 1120 gastric cancer patients and 1134 health examiners enrolled in this study.
Fangxuan Li, Jinli Dou, Lijuan Wei, Shixia Li, Juntian Liu   +4 more
doaj   +1 more source