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Resistance to cancer chemotherapy
Medical Hypotheses, 1986Human cancers are either refractory to chemotherapy, or acquire resistance to it. Although acquired resistance to chemotherapy is generally ascribed to the drug itself, it may be linked with the nature of neoplasia, since normal tissues e.g. gastrointestinal mucosa or bone marrow, do not seem to acquire resistance and their perpetuating sensitivity ...
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Shock, 2006
Part I. Physiological Resistance The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, and Chuan-Yuan Li Influence of Tumor pH on Therapeutic Response Chang W. Song, Robert Griffin, and Heon Joo Park Tumor Oxygenation and Treatment Response Sarah Jane Lunt and Richard P.
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Part I. Physiological Resistance The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, and Chuan-Yuan Li Influence of Tumor pH on Therapeutic Response Chang W. Song, Robert Griffin, and Heon Joo Park Tumor Oxygenation and Treatment Response Sarah Jane Lunt and Richard P.
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Multidrug Resistance in Cancer
2009It is becoming increasingly clear that the proliferation of human tumours is driven by a small proportion of cells, termed tumour stem cells, which have the properties of self-renewal. On analogy with stem cells for normal tissues, there are likely to be multiple mechanisms, involving both intrinsic cellular properties and microenvironmental factors ...
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Resistance mechanisms to cancer chemotherapy
Frontiers in Bioscience, 2008Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro ...
Redmond, K.M. +3 more
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MicroRNAs and Cancer Drug Resistance
2016The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene regulation. The class of microRNAs (miRs), a group of small noncoding RNAs (20-22 nt in length) that bind imperfectly to the 3'-untranslated region of target mRNA, has been insistently implicated in several pathological conditions including cancer.
Bruno Costa, Gomes +2 more
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A cancer therapy resistant to resistance
Nature, 1997The relentless growth of tumours depends on a good blood supply, and thus on subverting host mechanisms for making blood vessels. Attack on that process provides a promising route for treating cancer, but one that may take some years to reach clinical fruition.
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Multidrug resistance in human cancer
Journal of Neuro-Oncology, 1994Resistance to cytotoxic chemotherapy continues to be a major obstacle to more effective treatment of human cancers. A particular problem in clinical cancer chemotherapy is the phenomenon of simultaneous resistance of cancers to a variety of unrelated cytotoxic agents.
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Multidrug resistance in lung cancer
1994Lung cancer is divided into four major histological types: squamous cell carcinomas, adenocarcinomas, and large cell carcinomas, which are collectively referred to as non-small cell lung cancers (NSCLC), and a distinct type of lung cancer, small cell lung cancer (SCLC) [1].
H J, Broxterman +2 more
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, Kevin Outterson
exaly