Results 41 to 50 of about 1,730,139 (304)

Enigmatic exosomal connection in lung cancer drug resistance

Molecular Therapy: Nucleic Acids
Lung cancer remains a significant global health concern with limited treatment options and poor prognosis, particularly in advanced stages. Small extracellular vesicles such as exosomes, secreted by cancer cells, play a pivotal role in mediating drug ...
Sambit K. Patra, Rajeev K. Sahoo, Stuti Biswal, Shikshya S. Panda, Bijesh Kumar Biswal   +4 more
doaj   +1 more source

Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance

Cells, 2022
Here, we review the role of the circadian clock (CC) in the resistance of cancer cells to genotoxic treatments in relation to whole-genome duplication (WGD) and telomere-length regulation.
Ninel Miriam Vainshelbaum, Kristine Salmina, Bogdan I. Gerashchenko, Marija Lazovska, Pawel Zayakin, Mark Steven Cragg, Dace Pjanova, Jekaterina Erenpreisa   +7 more
doaj   +1 more source

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments [PDF]

, 2016
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and ...
Beck, Ilse, Bracke, Marc, Clarisse, Dorien, Offner, Fritz, Sundahl, Nora, Vanden Berghe, Wim   +5 more
core   +2 more sources

Why make it if you can take it: review on extracellular cholesterol uptake and its importance in breast and ovarian cancers

Journal of Experimental & Clinical Cancer Research
Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of cholesterol metabolism contributes to the pathogenesis of various diseases including cancer. Cancer cells are dependent on cholesterol.
Anna Røssberg Lauridsen, Aikaterini Skorda, Nuggi Ingholt Winther, Marie Lund Bay, Tuula Kallunki   +4 more
doaj   +1 more source

Development of a 5-FU modified miR-129 mimic as a therapeutic for non-small cell lung cancer

Molecular Therapy: Oncolytics, 2023
Lung cancer is the leading cause of cancer-related deaths in the United States with non-small cell lung cancer (NSCLC) accounting for most cases.
Ga-Ram Hwang, John G. Yuen, Andrew Fesler, Hannah Farley, John D. Haley, Jingfang Ju   +5 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence

Cell Death Discovery
Mitochondria integrate senescence and apoptotic fates, yet it is unclear whether their ability to oxidize different fuels for energy production influences their vulnerability to senolytics in therapy-induced senescence (TIS). Using MitoPlates™ technology,
Àngela Llop-Hernández, Sara Verdura, Júlia López, Begoña Martin-Castillo, Javier A. Menendez, Elisabet Cuyàs   +5 more
doaj   +1 more source

Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells. [PDF]

, 2017
Precision cancer medicine seeks to target the underlying genetic alterations of cancer; however, it has been challenging to use genetic profiles of individual patients in identifying the most appropriate anti-cancer drugs. This spurred the development of
Dall'Era, Marc A, de Vere White, Ralph W, Gheibi, Pantea, Ma, Ai-Hong, Pan, Chong-Xian, Revzin, Alexander, Son, Kyung Jin, Vu, Tam, Yap, Stanley Alexander, Zeng, Shuxiong   +9 more
core   +2 more sources

TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?

Membranes, 2023
Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ...
Mayar Soussi, Alice Hasselsweiller, Dimitra Gkika   +2 more
doaj   +1 more source

Overcoming Cancer Resistance [PDF]

Future Medicinal Chemistry, 2015
Katherine L Cook Department of Oncology & Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA and Department of Surgery, Hypertension & Vascular Research Center, Wake Forest University, Winston-Salem, NC 27157, USA “The need for new cancer therapies to target pathways involved in the development of ...
Katherine L Cook, Robert Clarke
openaire   +1 more source