Results 131 to 140 of about 2,125,565 (269)

Health Risk Assessment of Occupational Exposure to BTEX in the Painting unit of a Bicycle Industry in Quchan, Iran

تحقیقات سلامت در جامعه, 2020
Introduction and purpose: Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX) is regarded as one of the most important pollutants in organic compounds present in paint compounds the toxic effects of which are well known.
Mahmoud Mohammadyan, Hadi Naderi, Seyed Nouraddin Mousavinasab, Hadi Mahmoodi sharafe, Ali Rafiei, Mohammad Dasturani   +5 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.

, 2006
The 17 beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have ...
Pike, M.C., Kolonel, LN, Kraft, P, Burtt, N.P., Thun, MJ, Berglund, Göran,, Peeters, P.H.M., Buring, JE, Peeters, PH, LeMarchand, L., Albanes, D, Riboli, E., Freedman, ML, Haiman, CA, Chanock, S.J., Henderson, B.E., Thomas, G., Diver, W.R., Trichopoulos, D., Riboli, E, Stram, DO, Linseisen, J., Burtt, NP, Navarro, C, Hayes, R.B., Chanock, SJ, Trichopoulos, D, Albanes, D., Hirschhorn, J.N., Kolonel, L.N., Altshuler, D, Cann, HM, Feigelson, H.S., Wacholder, S., Cox, DG, LeMarchand, L, Pike, MC, Lund University., Tjonneland, A., Berrino, F., Freedman, M.L., Setiawan, V.W., Hunter, D., Kraft, P., Bingham, S, Berglund, Göran, Hankinson, SE, Colditz, G, Setiawan, VW, Berglund, G., Colditz, G., Cann, H.M., Feigelson, HS, Hankinson, S.E., Linseisen, J, Altshuler, D., Haiman, C.A., Hirschhorn, JN, Thomas, G, Berrino, F, Clavel-Chapelon, F, Modi, W, Clavel-Chapelon, F., Henderson, BE, Stram, D.O., Navarro, C., Calle, EE, Tjonneland, A, Buring, J.E., Diver, WR, Calle, E.E., Hayes, RB, Kaaks, R, Kaaks, R., Modi, W., Wacholder, S, Hunter, D, Cox, D.G., Thun, M.J.   +78 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Polymyalgia rheumatica and cancer risk: the importance of the diagnostic set

Open Access Rheumatology: Research and Reviews, 2016
Ciro Manzo,1 Maria Natale2 1Department of Geriatric and Internal Medicine, 2Geriatric Rheumatologic Outpatient Clinic, Hospital “Mariano Lauro,” Sant’Agnello, Naples, Italy Abstract: In the last few years, the relationship between ...
Manzo C, Natale M
doaj  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source