Results 111 to 120 of about 974,959 (300)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A mathematical insight in the epithelial-mesenchymal-like transition in cancer cells and its effect in the invasion of the extracellular matrix

, 2015
Current biological knowledge supports the existence of a secondary group of cancer cells within the body of the tumour that exhibits stem cell-like properties.
Hellmann, Nadja, Kolbe, Niklas, Sfakianakis, Nikolaos   +2 more
core  

Controlling the Bureaucracy of the Antipoverty Program [PDF]

, 1966
Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial ...
Abounit, Armstrong, Auernheimer, Bae, Banito, Banito, Bao, Bass, Basu-Roy, Beier, Ben-Porath, Binyamin, Bitarte, Booth, Brand, Cantz, Cao, Case, Chappell, Chen, Chen, Chen, Chiou, Chylicki, Cobaleda, de Cremoux, Denishefsky, Dickinson, Doi, Eberhard, Egler, Eshghi, Esteban, Evans, Fagin, Feinstein, Feng, Feng, Fimia, Fusaki, Galli, Ghavami, Ghavami, Ghavami, Ghavami, Ghule, Girouard, Godar, Gore, Guo, Guo, Gustafsson, Hanada, Hanley, Hanna, Harper, Hauff, Hellebrekers, Hench, Hench, Hench, Hockemeyer, Hoffmeyer, Hong, Hotta, Hu, Huang, Jain, Jangamreddy, Jangamreddy, Jeter, Jia, Jia, Jia, Junttila, Kaji, Kang, Karimi-Busheri, Kawamura, Kharas, Kim, Kim, Kochhar, Kumar, Lafontan, Lee, Lefebvre, Lengerke, Li, Li, Liu, Liu, Maddika, Marchetto, Marion, Matsuoka, Matsuura, Menendez, Menendez, Mikkelsen, Miller, Miura, Mizuno, Moawad, Momcilovic, Mortensen, Nadiminty, Nagata, Nakagawa, Nakagawa, Nakatogawa, Neumann, Okita, Okita, Okita, Oliver, Parry, Patel, Peng, Place, Plews, Prigione, Ravikumar, Reya, Ribatti, Rius, Rotter, Rowland, Rubinsztein, Ruoslahti, Räisänen, Sabisz, Saigusa, Salemi, Sato, Schenke-Layland, Shan, Singh, Singh, Sommer, Sridharan, Stadtfeld, Stolzenburg, Suhr, Suo, Takahashi, Tirino, Tsai, Tsaousi, Uchino, Vafa, van den Berg, van Tuyn, Vazquez, Vessoni, Vierbuchen, Vincent, Viswanathan, Viswanathan, Wang, Warren, Wary, Wernig, West, Wiechec, Wiechec, Wilmut, Woltjen, Wu, Xynos, Yamanaka, Yang, Yoshida, Yoshimori, Yu, Zbinden, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou, Zreiqat   +184 more
core   +4 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Isolation of Multipotent Mesenchymal Stem Cells from Human Extraocular Muscle Tissue

Bio-Protocol, 2019
Mesenchymal stem cells (MSCs) have attracted significant attention as potential therapeutic cells to treat various diseases ranging from tissue injuries, graft versus host disease, degenerative diseases and cancer.
Amit Sharma, Darilang Mawrie, Damarais Magdalene, Bithiah Jaganathan   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mutational signatures in colon cancer. [PDF]

, 2019
ObjectiveRecently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often.
Marjoram, Paul, Pandey, Priyatama, Shibata, Darryl, Siegmund, Kimberly D, Yang, Zhi   +4 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

LIVER CANCER STEM CELLS

Trakya University Journal of Natural Sciences, 2019
Recent studies have shown that many tumours are containing small population of stem cell-like cells, in other words, cancer stem cells. The rapid development of the cancer stem cell field has allowed the scientists and the clinicians to focus on another challenge, which targets cancer stem cells for new therapeutic strategies. Studies showed that novel
openaire   +5 more sources