Results 91 to 100 of about 3,487,182 (349)

Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway

Translational Oncology, 2021
Background: Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders ...
Kaili Liu, Jincheng Song, Yue Yan, Kun Zou, Yuxuan Che, Beichen Wang, Zongjuan Li, Wendan Yu, Wei Guo, Lijuan Zou, Wuguo Deng, Xiuhua Sun   +11 more
doaj   +1 more source

Emerging Evidence for MicroRNAs as Regulators of Cancer Stem Cells [PDF]

, 2014
Cancer stem cells are defined as a subpopulation of cells within a tumor that are capable of self-renewal and differentiation into the heterogeneous cell lineages that comprise the tumor.
Sethi, Aisha, Sholl, Lynette M.
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway

Cells, 2021
Over recent years, several Cys2-His2 (C2H2) domain-containing proteins have emerged as critical players in repairing DNA-double strand breaks. Human FLYWCH1 is a newly characterised nuclear transcription factor with (C2H2)-type zinc-finger DNA-binding ...
Sheema Almozyan, James Coulton, Roya Babaei-Jadidi, Abdolrahman S. Nateri   +3 more
doaj   +1 more source

Stemming Cancer: Functional Genomics of Cancer Stem Cells in Solid Tumors [PDF]

, 2008
Cancer stem cells (CSCs) were discovered about 15 years ago in hematopoietic cancers. Subsequently, cancer stem cells were discovered in various solid tumors. Based on parallels with normal stem cells, a developmental process of cancer stem cells follows
C. R. A. Regenbrecht, H. Lehrach, J. Adjaye, J. A. Thomson, L. Gepstein, P. W. Zandstra, C. H. Park, T. Chiba, T. Kondo, L. Patrawala, N. Mitsutake, M. F. Clarke, W. A. Woodward, J. Dou, M. Al-Hajj, N. Uchida, S. K. Singh, W. Matsui, M. E. Prince, C. Li, P. Dalerba, C. A. O’Brien, L. Ricci-Vitiani, H. D. Hemmati, B. A. Reynolds, S. K. Singh, S. Tamaki, D. Fang, M. Mimeault, A. T. Collins, A. Berns, M. F. Clarke, S. Bao, T. M. Phillips, G. Liu, G. Liu, D. Hambardzumyan, E. R. Blazek, R. Liu, M. Shipitsin, X. He, T. S. Huang, A. S. Advani, N. Boissel, M. Stanulla, T. J. Musci, Y. Nishita, G. Dennis Jr., J. Wixon, Y. Babaie, B. Greber, J. Taipale, A. Ruiz i Altaba, A. V. Molofsky, I. K. Park, J. Lessard, M. Kasper, C. D. Peacock, S. Liu, E. E. Bar, V. Clement, N. Reguart, T. Reya, T. Reya, C. H. Jamieson, J. B. Sneddon, L. Ye, K. A. Waite, S. G. Piccirillo, N. A. Lobo, D. J. Rossi, B. Greber, E. Fuchs, M. Egeblad, P. A. Kenny, T. D. Palmer, Q. Shen, C. Calabrese, A. Albini, M. Dean, D. Steinbach, S. Zhou, R. T. Costello, M. L. Guzman, D. Hanahan, K. J. Hope   +85 more
core   +1 more source

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Oncogene, 2010
Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions (EMT) are transdifferentiation programs that are required for tissue ...
Anurag Singh, J. Settleman
semanticscholar   +1 more source

Cancerous stem cells: deviant stem cells with cancer-causing misbehavior [PDF]

Stem Cell Research & Therapy, 2010
Stem cells maintain homeostasis in adult tissues via self-renewal and generation of terminally differentiated cells. Alterations in this intricate balance can result in disease. It has become increasingly evident that cancer can be initiated at the level of stem cells.
Chandler, Julie M, Lagasse, Eric
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Enhanced feature matching in single-cell proteomics characterizes IFN-γ response and co-existence of cell states

Nature Communications
Proteome analysis by data-independent acquisition (DIA) has become a powerful approach to obtain deep proteome coverage, and has gained recent traction for label-free analysis of single cells.
Karl K. Krull, Syed Azmal Ali, Jeroen Krijgsveld   +2 more
doaj   +1 more source

Targeting the epigenetic addiction of Merkel cell carcinoma

EMBO Molecular Medicine, 2020
Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine cancer of the skin, with very limited therapeutic options. Although immunotherapy is effective in some cases, there is an unmet need for new therapeutic approaches in MCCs.
Federico Mauri, Cédric Blanpain
doaj   +1 more source