Results 81 to 90 of about 3,487,182 (349)

PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription

Cell Reports, 2013
Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer, Gaetano Verde, Paola Pisano, Henrik Molina, Jofre Font-Mateu, Luciano Di Croce, Miguel Beato   +6 more
doaj   +1 more source

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Signal Transduction and Targeted Therapy, 2023
Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely ...
Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi   +17 more
doaj   +1 more source

Cancer stem cells display extremely large evolvability alternating plastic and rigid networks as a potential mechanism Network models, novel therapeutic target strategies, and the contributions of hypoxia, inflammation and cellular senescence [PDF]

, 2015
Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late
Achuthan, Altieri, Axelrod, Bao, Bergman, Birnie, Bissell, Bonavia, Bonnet, Bozóky, Brede, Breitkreutz, Buganim, Burrell, Caussinus, Chefetz, Chen, Cicalese, Clarke, Clarke, Collado, Conboy, Csermely, Csermely, Csermely, Csermely, Csermely, Csermely, Csikász-Nagy, Dejosez, Derenyi, Dezső Módos, Di Fiore, Ding, Du, Dulbecco, Dániel V. Veres, Earl, Eliasson, Flaberg, Greaves, Guck, Gupta, Gupta, Guven Maiorov, Gyurkó, Gáspár, Gómez-López, Hale, Harless, Hoek, Hornberg, Huang, Huang, Huang, Iakoucheva, Jin, János Hódsági, Katalin Lenti, Katsuno, Kauffman, Kelly, Kim, Kirschner, Kitano, Klein, Kovács, Kristóf Szalay, La Porta, Lapidot, Leal, Lee, Ling-Yun Wu, Liu, Liu, Lopes, Mahmoudabadi, Maitland, Malanchi, Mani, Markert, Meacham, Mihalik, Miranda, Mohanty, Müller, Nagata, Nussinov, Peacock, Peter Csermely, Pine, Polytarchou, Pujadas, Quintana, Rajapakse, Ren, Rheinbay, Roesch, Sharma, Shimono, Shiozawa, Sugiarto, Szalay, Szalay-Bekő, Tamás Korcsmáros, Tang, Teschendorff, Tian, Tothova, Trinchieri, Uversky, Vazquez-Martin, Verkman, Vermeulen, Vermeulen, Virchow, Volinia, Wang, Wang, Wang, Waters, Welford, Wellner, Werbowetski-Ogilvie, West, Wickliffe, Wu, Xiang-Sun Zhang, Xin, Xin, Yin, Yu, Zhang, Zhao, Zucchi, Áron R. Perez-Lopez   +135 more
core   +2 more sources

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

Molecular Cancer, 2017
BackgroundThe initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity.
C. Melzer, J. von der Ohe, H. Lehnert, H. Ungefroren, R. Hass   +4 more
semanticscholar   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

BPTF inhibition antagonizes colorectal cancer progression by transcriptionally inactivating Cdc25A

Redox Biology, 2022
As the largest subunit of the nuclear remodeling factor complex, Bromodomain PHD Finger Transcription Factor (BPTF) has been reported to be involved in tumorigenesis and development in several cancers.
Ping Guo, Shijia Zu, Shilong Han, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin, Xinrui Zhao, Haibo Lu, Chunyu Hua, Xinyu Wan, Liyuan Ru, Ziyue Guo, Hanxiao Ge, Kuan Lv, Guohui Zhang, Wuguo Deng, Cheng Luo, Wei Guo   +18 more
doaj   +1 more source

Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]

, 2013
We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms
Napoletani, Domenico, Signore, Michele, Struppa, Daniele C.   +2 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A Role for RUNX3 in Inflammation-Induced Expression of IL23A in Gastric Epithelial Cells

Cell Reports, 2014
RUNX3 functions as a tumor suppressor in the gastric epithelium, where its inactivation is frequently observed during carcinogenesis. We identified IL23A as a RUNX3 target gene in gastric epithelial cells.
Yit Teng Hor, Dominic Chih-Cheng Voon, Jason Kin Wai Koo, Huajing Wang, Wen Min Lau, Hassan Ashktorab, Shing Leng Chan, Yoshiaki Ito   +7 more
doaj   +1 more source

A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells

eJHaem, 2021
Recent advances in treatment options for multiple myeloma (MM) have positive impact on patient survival. However, there is a short fall of rapid and reliable assays that can predict patient response to novel agents.
Martin Grundy, Firas Al‐Kaisi, Joanna Cull, Cathy Williams, Dean Smith, Claire H. Seedhouse   +5 more
doaj   +1 more source