Results 61 to 70 of about 3,487,182 (349)
PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer
BMC Cancer, 2020 Background PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate that PPFIA1 is an important promoter
Lutfi H. Alfarsi +6 more
doaj +1 more source
Lipid storage and autophagy in melanoma cancer cells [PDF]
, 2017 Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina +9 more
core +2 more sources
Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]
, 2015 Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John +5 more
core +1 more source
Cancer, stem cell misplacement and cancer stem cells
Journal of Cellular and Molecular Medicine, 2013 AbstractThe cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi‐stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis ...
openaire +2 more sources
Cancer stem cells in osteosarcoma [PDF]
Cancer Letters, 2017 Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets.
Heymann, D. +2 more
openaire +3 more sources
Transfection of hPSC-Cardiomyocytes Using Viafect™ Transfection Reagent
Methods and Protocols, 2020 Twenty years since their first derivation, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have shown promise in disease modelling research, while their potential for cardiac repair is being investigated.
Sara E. Bodbin +2 more
doaj +1 more source
Complexity in cancer stem cells and tumor evolution: towards precision medicine [PDF]
, 2017 In this review, we discuss recent advances on the plasticity of cancer stem cells and highlight their relevance to understand the metastatic process and to guide therapeutic interventions.
La Porta, Caterina A. M. +1 more
core +2 more sources
The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells?
Cell Stem Cell, 2015 Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity and clonal long-term repopulation potential.
V. Plaks, Niwen Kong, Z. Werb
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi +20 more
wiley +1 more source
Breast Cancer Research, 2018 Background Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC although its impact on patient outcome in different BC subtypes remains to be validated.
Rokaya El Ansari +7 more
doaj +1 more source