Results 61 to 70 of about 7,194,876 (206)
Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]
, 2015 The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR +11 more
core +1 more source
Neural stem cells in development and cancer [PDF]
, 2008 Neural stem cells are defined by their unique ability to undergo self-renewal divisions. By dividing asymmetrically, a stem cell simultaneously produces a daughter cell that retains stem cell identity, whereas the other starts to differentiate and ...
Waldhuber, Markus
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]
, 2006 A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G +14 more
core +1 more source
Cancer Stem Cells in Cancer Initiation and Progression
, 2023 Cancer stem cells (CSCs) are a subclass of cancer cells that can differentiate into various cell types and self-renew, similar to normal stem cells. CSCs play an important role in the initiation and progression of cancer, and as such, there has been ...
Masoudi, R, Gopalan, V
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Cancer stem cells and targeting strategies [PDF]
, 2019 Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms that counteract the effect of chemotherapeutic compounds, leading to relapse and the development of more aggressive cancers that contribute to poor prognosis and ...
Luisa Barbato +7 more
core +1 more source