Results 51 to 60 of about 3,487,182 (349)

Cancer stem cell subsets and their relationships [PDF]

, 2011
Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified, a variety of differences among them began to be ...
Hai-Guang Liu, Chong Chen, Han Yang, Yi-Fei Pan, Xiao-Hua Zhang   +4 more
core   +2 more sources

The role of P63 in cancer, stem cells and cancer stem cells [PDF]

Cellular and Molecular Biology Letters, 2011
AbstractThe transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 ...
Nekulova, Marta, Holcakova, Jitka, Coates, Philip, Vojtesek, Borivoj   +3 more
openaire   +3 more sources

ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Cells, 2019
Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown.
Reem Ali, Muslim Alabdullah, Islam Miligy, Makhliyo Normatova, Roya Babaei-Jadidi, Abdolrahman S. Nateri, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source

Cancer stem cells in prostate cancer: implications for targeted therapy [PDF]

, 2017
Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world.
Castelo-Branco, Pedro, Domingos, Célia, Figueiredo, Arnaldo, Hamilton, Robert, Leao, Ricardo, Tabori, Uri   +5 more
core   +1 more source

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Stem Cells International, 2018
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer ...
L. Phi, I. N. Sari, Ying-Gui Yang, Sanghyun Lee, Nayoung Jun, K. Kim, Y. Lee, H. Kwon   +7 more
semanticscholar   +1 more source

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine [PDF]

, 2011
Embryonic stem (ES) cells are of great interest as a model system for studying early developmental processes and because of their potential therapeutic applications in regenerative medicine.
Kim, Jonghwan, Orkin, Stuart
core   +1 more source

Association of Reactive Oxygen Species Levels and Radioresistance in Cancer Stem Cells

Nature, 2009
The metabolism of oxygen, although central to life, produces reactive oxygen species (ROS) that have been implicated in processes as diverse as cancer, cardiovascular disease and ageing.
M. Diehn, Robert W. Cho, N. Lobo, T. Kalisky, M. Dorie, A. Kulp, Dalong Qian, Jessica S. Lam, Laurie E. Ailles, Manzhi Wong, Benzion Joshua, M. J. Kaplan, I. Wapnir, F. Dirbas, G. Somlo, C. Garberoglio, B. Paz, Jeannie Shen, S. Lau, Stephen R. Quake, J. Brown, I. L. Weissman, Michael F. Clarke   +22 more
semanticscholar   +1 more source

EMT, cancer stem cells and autophagy; The three main axes of metastasis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways involved in both processes are appropriate therapeutic targets in the ...
G. Babaei, S. Aziz, Nasrin Zare Zavieyh Jaghi   +2 more
semanticscholar   +1 more source

Cancer Stem Cells and Chemosensitivity [PDF]

Clinical Cancer Research, 2011
Abstract Cancer lethality is mainly due to the onset of distant metastases and refractoriness to chemotherapy. Thus, the development of molecular targeted agents that can restore or increase chemosensitivity will provide valuable therapeutic options for cancer patients.
Maugeri Saccà M, VIGNERI, PAOLO, De Maria R.   +2 more
openaire   +3 more sources

Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling

Biomolecules
As a kind of proteolytic enzyme extracted from earthworms, lumbrokinase has been used as an antithrombotic drug clinically. Nevertheless, its potential in anti-cancer, especially in anti-non-small cell lung cancer (NSCLC), as a single form of treatment ...
Chunyu Hua, Ziyue Guo, Meng Dai, Jie Zhou, Hanxiao Ge, Guoqing Xue, Fahui Xu, Liyuan Ru, Kuan Lv, Guohui Zhang, Lina Zheng, Meiyi Wang, Yun Teng, Wendan Yu, Wei Guo   +14 more
doaj   +1 more source