Results 31 to 40 of about 3,487,182 (349)
Molecular Oncology, 2021 Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal cancer (CRC). However, the precise upstream regulatory mechanisms of hTERT in different cancer types remain poorly
Chaoliang Diao +22 more
doaj +1 more source
Journal of Thoracic Oncology, 2009 Solid tumors are comprised of a surprisingly heterogeneous collection of cells. As discussed in an introductory talk by Dr. Rudin, recent studies focused on a wide diversity of malignancies have begun to define phenotypically distinct subsets of cancer cells that differ in terms of both clonogenic potential in vitro and tumorigenic potential in vivo ...
Rudin, Charles, Minna, John
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BMC Cancer, 2018 Background P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a ...
Simon J. Johnston +7 more
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
, 2020 Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A. +11 more
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Cancer stem cells in glioblastoma
Genes & Development, 2015 Glioblastoma is the most prevalent and malignant primary brain tumor, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. In this review, Lathia et al. discuss how the integration
J. Lathia +4 more
semanticscholar +1 more source
Protease‐resistant streptavidin for interaction proteomics
Molecular Systems Biology, 2020 Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners; however, intense streptavidin‐derived peptides impede protein identification by mass spectrometry.
Mahmoud‐Reza Rafiee +6 more
doaj +1 more source
Single cell transcriptome atlas of mouse mammary epithelial cells across development
Breast Cancer Research, 2021 Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling.
Bhupinder Pal +12 more
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Chemical approaches to targeting drug resistance cancer stem cells [PDF]
, 2016 STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Blaire Theuma, Krystle +6 more
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Identification of selective inhibitors of cancer stem cells by high-throughput screening
Cell, 2009 Summary Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture.
Piyush B. Gupta +6 more
semanticscholar +1 more source
Forces in stem cells and cancer stem cells
Cells & Development, 2022 Endogenous and exogenous forces are critical in physiology and pathology of the human body. Increasing evidence suggests that these forces, mechanics, and force-associated signaling are essential in regulating functions of living cells. Here we review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem ...
Farhan, Chowdhury, Bo, Huang, Ning, Wang
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