Results 11 to 20 of about 549,560 (263)
Postępy Higieny i Medycyny Doświadczalnej, 2012 Cancer stem cell theory gains increasingly greater significance in the world of medicine. Numerous findings of scientific research in vivo and in vitro indicate that it is the population of undifferentiated, self-renewing cells which is responsible for recurrence of cancer and metastasis. Similarly to normal stem cells, cancer stem cells (CSC) function
Katarzyna, Wieczorek +1 more
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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment [PDF]
Stem Cells International, 2017 Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence, proliferation, and regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer Stem Cells (CSCs) behave as their ...
Pedro M. Aponte, Andrés Caicedo
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Stem cells, cancer, and cancer stem cells [PDF]
Nature, 2001 Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Reya, T. +3 more
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Stemness, cancer, and cancer stem cells [PDF]
Cell Cycle, 2008 The ability of cancers to grow indefinitely has fueled the idea that cancer and stem cells may have common underlying mechanisms. Detailed gene expression maps have now shown the diversity and distinctiveness in gene expression programs associated with stemness in embryonic and adult stem cells. These maps have further revealed a shared transcriptional
David J, Wong +2 more
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Cells, Stem Cells, and Cancer Stem Cells [PDF]
Seminars in Reproductive Medicine, 2013 The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
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Experimental Biology and Medicine, 2021 Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. A tremendous effort has been made to understand the origin of cancer cells, the formation of cancerous tissues, and the mechanism by which they spread and relapse, but the disease still remains ...
Wen Yin +3 more
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Journal of Oncology, 2011 The concept of cancer stem cells has generated significant interests among cancer researchers. This has led to proliferative number of publications on the subject in the recent years and eventually controversies because of conflicting data in the literature.
Lu, Bo +3 more
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Journal of Thoracic Oncology, 2009 Solid tumors are comprised of a surprisingly heterogeneous collection of cells. As discussed in an introductory talk by Dr. Rudin, recent studies focused on a wide diversity of malignancies have begun to define phenotypically distinct subsets of cancer cells that differ in terms of both clonogenic potential in vitro and tumorigenic potential in vivo ...
Rudin, Charles, Minna, John
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Protease‐resistant streptavidin for interaction proteomics
Molecular Systems Biology, 2020 Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners; however, intense streptavidin‐derived peptides impede protein identification by mass spectrometry.
Mahmoud‐Reza Rafiee +6 more
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Single cell transcriptome atlas of mouse mammary epithelial cells across development
Breast Cancer Research, 2021 Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling.
Bhupinder Pal +12 more
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