Results 11 to 20 of about 7,194,876 (206)

Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]

, 2010
A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core   +6 more sources

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. [PDF]

, 2013
Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Tunici, P, Stephan A. Hahn (423002), Hidalgo Manuel, Annette Bakker (109705), Trabulo Sara M., Hermann, PC, Hahn, SA, Patrizia Tunici (109691), Patrick C. Hermann, Hahn Stephan A., Vandana, M, Sanjeeb K. Sahoo (176483), Sahoo Sanjeeb K., Sainz, B, Sainz Bruno, Anamaria Balic (423000), Garcia Elena, Tunici Patrizia, Manuel Hidalgo, Balic, A, Balic Anamaria, Stephan A. Hahn, Vandana Mallaredy, Elena Garcia (423001), Stephan A Hahn, Christopher Heeschen (373899), Sahoo, SK, Patrizia Tunici, Bakker Annette, Mallaredy Vandana, Heeschen Christopher, Patrick C Hermann, Bruno Sainz, Sara M Trabulo, Sara M. Trabulo, Christopher Heeschen, Patrick C. Hermann (422997), Garcia, E, Mallaredy Vandana (423003), Elena Garcia, Sanjeeb K Sahoo, Heeschen, C, Manuel Hidalgo (7235), Bakker, A, Bruno Sainz Jr (422999), Sanjeeb K. Sahoo, Hermann Patrick C., Sara M. Trabulo (422998), Trabulo, SM, Anamaria Balic, Hidalgo, M, Annette Bakker   +51 more
core   +2 more sources

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
Background:Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
Y Liu, Appleyard, M. V., M V Appleyard, Liu, Y., P J Coates, Thompson, A. M., Boylan, M., Coates, P. J., Nenutil, R., M Boylan, A M Thompson, Murray, K., R Nenutil, K Murray   +13 more
core   +1 more source

Identification, properties, and clinical significance of putative stem-like cell populations in prostate cancer [PDF]

, 2012
The notion that tumour initiation and heterogeneity might be driven by small population of tumour-initiating cells (TIC) has gained high significance since the pioneering identification of TIC in leukaemia.
Le Magnen, Clémentine
core   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Jauch, Karl-Walter, Bao, Q., Niess, H., Bruns, Christiane J., Zhao, L., Zhao, Y.   +5 more
core   +1 more source

Protease‐resistant streptavidin for interaction proteomics

Molecular Systems Biology, 2020
Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners; however, intense streptavidin‐derived peptides impede protein identification by mass spectrometry.
Mahmoud‐Reza Rafiee, Gianluca Sigismondo, Mathias Kalxdorf, Laura Förster, Britta Brügger, Julien Béthune, Jeroen Krijgsveld   +6 more
doaj   +1 more source

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

BMC Cancer, 2020
Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse   +4 more
doaj   +1 more source

Single cell transcriptome atlas of mouse mammary epithelial cells across development

Breast Cancer Research, 2021
Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling.
Bhupinder Pal, Yunshun Chen, Michael J. G. Milevskiy, François Vaillant, Lexie Prokopuk, Caleb A. Dawson, Bianca D. Capaldo, Xiaoyu Song, Felicity Jackling, Paul Timpson, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader   +12 more
doaj   +1 more source

Chemical approaches to targeting drug resistance cancer stem cells [PDF]

, 2016
STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Micallef, Neville, Cassar, Analisse, Stipourou, Iona, Blaire Theuma, Krystle, Suleiman, Sherif, Schembri-Wismayer, Pierre, Passarella, Daniele   +6 more
core   +1 more source

RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers

Molecular Biomedicine, 2020
Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key route to platinum resistance.
Adel Alblihy, Muslim L. Alabdullah, Michael S. Toss, Mashael Algethami, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan   +6 more
doaj   +1 more source