Results 11 to 20 of about 546,265 (263)
Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment
Clinical and Translational Medicine, 2021 Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influences ...
Shaikha AlMusawi +2 more
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Frontiers in Physiology, 2022 Cancer tissue consists of heterogenous cell types, and cancer stem cells (CSCs) are a subpopulation of the tissue which possess therapy resistance, tumor reconstruction capability, and are responsible for metastasis. Intrahepatic cholangiocarcinoma (iCCA)
Keiichi Tamai +3 more
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Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant
Scientific Reports, 2021 In vitro, depending on extracellular matrix (ECM) architecture, macrophages migrate either in amoeboid or mesenchymal mode; while the first is a general trait of leukocytes, the latter is associated with tissue remodelling via Matrix Metalloproteinases ...
Jana Travnickova +6 more
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Journal of Oncology, 2011 The concept of cancer stem cells has generated significant interests among cancer researchers. This has led to proliferative number of publications on the subject in the recent years and eventually controversies because of conflicting data in the literature.
Lu, Bo +3 more
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IFNα-mediated remodeling of endothelial cells in the bone marrow niche
Haematologica, 2017 In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast +5 more
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Context Dependency of Epithelial-to-Mesenchymal Transition for Metastasis
Cell Reports, 2019 Summary: Epithelial-to-mesenchymal transition (EMT) has been proposed to be important for metastatic dissemination. However, recent studies have challenged the requirement of EMT for metastasis.
Tatiana Revenco +10 more
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Journal of Thoracic Oncology, 2009 Solid tumors are comprised of a surprisingly heterogeneous collection of cells. As discussed in an introductory talk by Dr. Rudin, recent studies focused on a wide diversity of malignancies have begun to define phenotypically distinct subsets of cancer cells that differ in terms of both clonogenic potential in vitro and tumorigenic potential in vivo ...
Rudin, Charles, Minna, John
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Molecular Oncology, 2021 Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal cancer (CRC). However, the precise upstream regulatory mechanisms of hTERT in different cancer types remain poorly
Chaoliang Diao +22 more
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BMC Cancer, 2018 Background P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a ...
Simon J. Johnston +7 more
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Protease‐resistant streptavidin for interaction proteomics
Molecular Systems Biology, 2020 Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners; however, intense streptavidin‐derived peptides impede protein identification by mass spectrometry.
Mahmoud‐Reza Rafiee +6 more
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