Results 1 to 10 of about 3,487,033 (207)
Therapy resistance on the RADar in ovarian cancer
EMBO Molecular Medicine, 2021 Ovarian cancer has the worst prognosis of all gynecological cancers with high‐grade serous ovarian cancer (HGSOC) accounting for the majority of ovarian cancer deaths.
Jonas Schwickert +2 more
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Heliyon, 2023 The mammary gland (MG) is composed of three main epithelial lineages, the basal cells (BC), the estrogen receptor (ER) positive luminal cells (ER+ LC), and the ER negative LC (ER− LC).
Yura Song +5 more
doaj +1 more source
Scientific Reports, 2022 Poly(A) binding protein nuclear 1 (PABPN1) is known for its role in poly(A) tail addition and regulation of poly(A) tail length. In addition, it has been shown to be involved in alternative polyadenylation (APA).
Pia Sommerkamp +10 more
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Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers [PDF]
, 2013 Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived ...
Gutenkunst, Ryan N., Jilkine, Alexandra
core +5 more sources
Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. [PDF]
, 2016 The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade.
Banno, Asoka +15 more
core +7 more sources
Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment
Clinical and Translational Medicine, 2021 Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influences ...
Shaikha AlMusawi +2 more
doaj +1 more source
Frontiers in Physiology, 2022 Cancer tissue consists of heterogenous cell types, and cancer stem cells (CSCs) are a subpopulation of the tissue which possess therapy resistance, tumor reconstruction capability, and are responsible for metastasis. Intrahepatic cholangiocarcinoma (iCCA)
Keiichi Tamai +3 more
doaj +1 more source
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma
Cells, 2021 Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies.
Karina Biserova +3 more
semanticscholar +1 more source
Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]
, 2012 Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter +48 more
core +9 more sources
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
Frontiers in Immunology, 2020 The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identify several types
Lia Walcher +9 more
semanticscholar +1 more source