Results 21 to 30 of about 546,265 (263)
Single cell transcriptome atlas of mouse mammary epithelial cells across development
Breast Cancer Research, 2021 Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling.
Bhupinder Pal +12 more
doaj +1 more source
Forces in stem cells and cancer stem cells
Cells & Development, 2022 Endogenous and exogenous forces are critical in physiology and pathology of the human body. Increasing evidence suggests that these forces, mechanics, and force-associated signaling are essential in regulating functions of living cells. Here we review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem ...
Farhan, Chowdhury, Bo, Huang, Ning, Wang
openaire +2 more sources
RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers
Molecular Biomedicine, 2020 Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key route to platinum resistance.
Adel Alblihy +6 more
doaj +1 more source
BMC Cancer, 2020 Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali +4 more
doaj +1 more source
Phospho-protein Analysis in Adherent Cells Using Flow Cytometry
Bio-Protocol, 2019 Protein phosphorylation is one of the most important post-translational modifications, which acts as a reversible on or off switch for the activity of a large number of proteins.
Renu Sharma +3 more
doaj +1 more source
Haematologica, 2020 Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown ...
Elia Henry +9 more
doaj +1 more source
PTEN, Stem Cells, and Cancer Stem Cells [PDF]
Journal of Biological Chemistry, 2009 Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Reginald, Hill, Hong, Wu
openaire +2 more sources
Prostate Stem Cells and Cancer Stem Cells [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Jia J, Li, Michael M, Shen
openaire +2 more sources
The role of P63 in cancer, stem cells and cancer stem cells [PDF]
Cellular and Molecular Biology Letters, 2011 AbstractThe transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 ...
Nekulova, Marta +3 more
openaire +3 more sources
Cells, 2019 Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown.
Reem Ali +7 more
doaj +1 more source