Results 21 to 30 of about 7,194,876 (206)

Phospho-protein Analysis in Adherent Cells Using Flow Cytometry

Bio-Protocol, 2019
Protein phosphorylation is one of the most important post-translational modifications, which acts as a reversible on or off switch for the activity of a large number of proteins.
Renu Sharma, Amit Sharma, Atul Kumar, Bithiah Jaganathan   +3 more
doaj   +1 more source

Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations

Haematologica, 2020
Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown ...
Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefèvre, Vilma Barroca, Anna Campalans, Véronique Ménard, Julien Calvo, Françoise Pflumio, Marie-Laure Arcangeli   +9 more
doaj   +1 more source

Studies on the behaviour of human pancreatic carcinoma cell lines, with particular reference to stem cells [PDF]

, 2010
PhDStem cell therapy represents a potential -cell replacement strategy in diabetes and a pancreatic cancer (PC) stem cell is an attractive therapeutic target in this dire disease. However, a normal stem cell remains unidentified and proposed malignant
Guppy, Naomi J
core   +4 more sources

Identification of new markers for the characterization and isolation of breast cancer stem cells [PDF]

, 2013
Breast cancer is the first human carcinoma for which a putative cancer stem cell subpopulation (BCSC) has been isolated with the CD44+/CD24-/low phenotype.
Leccia, Felicia
core   +1 more source

ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Cells, 2019
Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown.
Reem Ali, Muslim Alabdullah, Islam Miligy, Makhliyo Normatova, Roya Babaei-Jadidi, Abdolrahman S. Nateri, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source

Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling

Biomolecules
As a kind of proteolytic enzyme extracted from earthworms, lumbrokinase has been used as an antithrombotic drug clinically. Nevertheless, its potential in anti-cancer, especially in anti-non-small cell lung cancer (NSCLC), as a single form of treatment ...
Chunyu Hua, Ziyue Guo, Meng Dai, Jie Zhou, Hanxiao Ge, Guoqing Xue, Fahui Xu, Liyuan Ru, Kuan Lv, Guohui Zhang, Lina Zheng, Meiyi Wang, Yun Teng, Wendan Yu, Wei Guo   +14 more
doaj   +1 more source

Drosophila Neural Stem Cells in Brain Development and Tumor Formation [PDF]

, 2014
Neuroblasts, the neural stem cells in Drosophila, generate the complex neural structure of the central nervous system. Significant progress has been made in understanding the mechanisms regulating the self-renewal, proliferation, and differentiation in ...
Reichert, Heinrich, Jiang, Yanrui
core   +1 more source

Transfection of hPSC-Cardiomyocytes Using Viafect™ Transfection Reagent

Methods and Protocols, 2020
Twenty years since their first derivation, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have shown promise in disease modelling research, while their potential for cardiac repair is being investigated.
Sara E. Bodbin, Chris Denning, Diogo Mosqueira   +2 more
doaj   +1 more source

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures [PDF]

, 2014
Objective Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%.
Patricia Kraehe, Kraehe Patricia, Shayan, Parviz, Lueders, Cora, Shayan Parviz, Lueders Cora, Shakibaei Mehdi, Mehdi Shakibaei, Parviz Shayan, Goel Ajay, Buhrmann Constanze, Ajay Goel, Cora Lueders, Shakibaei, Mehdi, Constanze Buhrmann, Buhrmann, Constanze, Goel, Ajay, Kraehe, Patricia   +17 more
core   +1 more source

PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer

BMC Cancer, 2020
Background PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate that PPFIA1 is an important promoter
Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha, Andrew R. Green   +6 more
doaj   +1 more source