Results 1 to 10 of about 387,984 (293)

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications [PDF]

Cancer Research, 2013
Abstract Accumulating evidence suggests that human cancers develop through a step-wise, but nonlinear process of cellular diversification and evolution. Recent mutational analyses indicate that this process is more complex and diverse than anticipated before whole-genome sequencing methods were readily available.
Peter, Valent, Dominique, Bonnet, Stefan, Wöhrer, Michael, Andreeff, Mhairi, Copland, Christine, Chomienne, Connie, Eaves   +6 more
openaire   +3 more sources

Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies

Stem Cells International, 2018
The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem
Ilaria Laurenzana, Daniela Lamorte, Stefania Trino, Luciana De Luca, Concetta Ambrosino, Pietro Zoppoli, Vitalba Ruggieri, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano, Geppino Falco   +10 more
doaj   +2 more sources

Microvesicles from Human Immortalized Cell Lines of Endothelial Progenitor Cells and Mesenchymal Stem/Stromal Cells of Adipose Tissue Origin as Carriers of Bioactive Factors Facilitating Angiogenesis

Stem Cells International, 2020
Endothelial progenitor cells (EPCs) and mesenchymal stem/stromal cells (MSCs) are associated with maintaining tissue homeostasis and tissue repair. Both types of cells contribute to tissue regeneration through the secretion of trophic factors (alone or ...
Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Honorata Kraskiewicz, Agnieszka Szyposzynska, Elżbieta Wojdat, Aleksandra Klimczak   +6 more
doaj   +1 more source

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

Brazilian Oral Research, 2021
The aim of this study was to identify tumor parenchyma cells exhibiting immunohistochemical profile of stem cells by evaluating the immunoreactivity of OCT4 and CD44 in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic
Jamile Marinho Bezerra de Oliveira Moura, Amanda Katarinny Goes Gonzaga, Salomão Israel Monteiro Lourenço Queiroz, Manoela Domingues Martins, Leão Pereira Pinto, Lélia Batista de Souza   +5 more
doaj   +1 more source

von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. [PDF]

PLoS Medicine, 2007
BACKGROUND: To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells from ...
Deric M Park, Zhengping Zhuang, Ling Chen, Nicholas Szerlip, Irina Maric, Jie Li, Taesung Sohn, Stephanie H Kim, Irina A Lubensky, Alexander O Vortmeyer, Griffin P Rodgers, Edward H Oldfield, Russell R Lonser   +12 more
doaj   +1 more source

Association between CD133 expression and clinicopathological profile in colorectal cancer [PDF]

Medicinski Glasnik, 2020
Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients. Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik General ...
Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf   +3 more
doaj   +1 more source

Cellullar Plasticity and Dedifferentiation: A Link Between Cancer Stem Cells, Hypoxia, Cell Injury, and Inflammation

Journal of Stem Cell Research and Tissue Engineering, 2019
Cellular plasticity is the concept of bidirectional dynamics change cells differentiation degree which involved in the regeneration, repair and tissue turnover along the organism livespan.
Andi Yasmin Wijaya
doaj   +1 more source

Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells

Nanomaterials, 2018
An innovative and environmentally friendly method for the synthesis of size-controlled silver nanoparticles (AgNPs) is presented. Pectin-stabilized AgNPs were synthesized in a plasma-reaction system in which pulse-modulated radio-frequency atmospheric ...
Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, George C. diCenzo, Piotr Jamroz, Jan Macioszczyk, Aleksandra Klimczak, Pawel Pohl   +6 more
doaj   +1 more source

Adult human mesenchymal stem cell as a target for neoplastic transformation [PDF]

Oncogene, 2004
The neoplastic process may involve a cancer stem cell. This concept has emerged largely from the careful analysis of tumour biopsy systems from haematological, breast and brain tumours. However, the experimental systems necessary to provide the cellular and molecular evidence to support this important concept have been lacking.
Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, Jensen T, Kassem M   +6 more
openaire   +4 more sources

Effects of Arf6 downregulation on biological characteristics of human prostate cancer cells [PDF]

International Brazilian Journal of Urology
Objective To evaluate the effects of Arf6 downregulation on human prostate cancer cells. Materials and Methods The effects of Arf6 downregulation on cell proliferation, migration, invasion and apoptosis were assessed by MTT, BrdU, scratch, Transwell ...
Haiming Lei, Fujun Ma, Renfeng Jia, Bo Tan   +3 more
doaj   +2 more sources