Results 1 to 10 of about 438,052 (300)

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells [PDF]

Nature Communications, 2017
Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal ...
Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew   +8 more
doaj   +7 more sources

Normal and Neoplastic Stem Cells. [PDF]

Cold Spring Harb Symp Quant Biol, 2016
A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation.
McCracken MN, George BM, Kao KS, Marjon KD, Raveh T, Weissman IL.   +5 more
europepmc   +4 more sources

Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms. [PDF]

Semin Cancer Biol, 2020
The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis.
Valent P, Sadovnik I, Eisenwort G, Herrmann H, Bauer K, Mueller N, Sperr WR, Wicklein D, Schumacher U.   +8 more
europepmc   +4 more sources

MicroRNAs involved in neoplastic transformation of liver cancer stem cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan, You Nan, Tao Kaishan, Qian Niansong, Li Ren, Dou Kefeng   +5 more
doaj   +3 more sources

Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells [PDF]

Cell Journal, 2011
The neoplastic niche comprises complex interactions between multiple cell typesand molecules requiring cell-cell signaling as well as local secretion. These nichesare important for both the maintenance of cancer stem cells and the inductionof neoplastic ...
Saeid Abroun, Najmaldin Saki, Farahnaz Asgharei, Majid Farshdousti Hagh   +3 more
doaj   +2 more sources

Cell surface GRP78 promotes stemness in normal and neoplastic cells [PDF]

Scientific Reports, 2020
Abstract Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been ...
Clay Conner, Tyson W. Lager, Ian H. Guldner, Min-Zu Wu, Yuriko Hishida, Tomoaki Hishida, Sergio Ruiz, Amanda E. Yamasaki, Robert C. Gilson, Juan Carlos Izpisua Belmonte, Peter C. Gray, Jonathan A. Kelber, Siyuan Zhang, Athanasia D. Panopoulos   +13 more
openaire   +3 more sources

Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. [PDF]

, 2011
Pluripotent stem cells (PSCs) hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal and potential to differentiate into every cell type in the body. One major barrier to the use of PSCs is their potential risk
Banerjee, Utpal, Clark, Amander T, Jiao, Jing, Li, Xinmin, Lindgren, Anne G, Natsuhara, Kyle, Tian, E, Vincent, John J, Wu, Hong   +8 more
core   +15 more sources

Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: From Research Perspectives to Clinical Practice

Cells, 2021
Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration. However, tracking cells and maintaining them in the site of injury is difficult. A potential solution is to seed the cells onto a biocompatible scaffold.
Sandra Stamnitz, Aleksandra Klimczak
doaj   +1 more source

Osteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold

Cells, 2022
Mesenchymal stem cells (MSCs) attract interest in regenerative medicine for their potential application in bone regeneration. However, direct transplantation of cells into damaged tissue is not efficient enough to regenerate large bone defects.
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szałaj, Żaneta Górecka, Agnieszka Antończyk, Zdzisław Kiełbowicz, Wojciech Święszkowski, Witold Łojkowski, Aleksandra Klimczak   +8 more
doaj   +1 more source

Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. [PDF]

PLoS ONE, 2014
INTRODUCTION: Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem
Monique Terwijn, Wendelien Zeijlemaker, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Willemijn J Scholten, Thomas Pabst, Gregor Verhoef, Bob Löwenberg, Sonja Zweegman, Gert J Ossenkoppele, Gerrit J Schuurhuis   +11 more
doaj   +1 more source