Results 11 to 20 of about 387,984 (293)

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells [PDF]

Nature Communications, 2017
Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal ...
Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew   +8 more
doaj   +10 more sources

Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms. [PDF]

Semin Cancer Biol, 2020
The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis.
Valent P, Sadovnik I, Eisenwort G, Herrmann H, Bauer K, Mueller N, Sperr WR, Wicklein D, Schumacher U.   +8 more
europepmc   +5 more sources

MicroRNAs involved in neoplastic transformation of liver cancer stem cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan, You Nan, Tao Kaishan, Qian Niansong, Li Ren, Dou Kefeng   +5 more
doaj   +5 more sources

Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells [PDF]

Cell Journal, 2011
The neoplastic niche comprises complex interactions between multiple cell typesand molecules requiring cell-cell signaling as well as local secretion. These nichesare important for both the maintenance of cancer stem cells and the inductionof neoplastic ...
Saeid Abroun, Najmaldin Saki, Farahnaz Asgharei, Majid Farshdousti Hagh   +3 more
doaj   +3 more sources

Normal and Neoplastic Stem Cells. [PDF]

Cold Spring Harb Symp Quant Biol, 2016
A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation.
McCracken MN, George BM, Kao KS, Marjon KD, Raveh T, Weissman IL.   +5 more
europepmc   +4 more sources

Neoplastic stem cells: A novel therapeutic target in clinical oncology [PDF]

Cancer, 2006
AbstractCancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy.
Axel Schulenburg, Herbert Ulrich-Pur, Boban M Erovic   +2 more
exaly   +3 more sources

Normal and neoplastic urothelial stem cells: getting to the root of the problem [PDF]

Nature Reviews Urology, 2012
Most epithelial tissues contain self-renewing stem cells that mature into downstream progenies with increasingly limited differentiation potential. It is not surprising that cancers arising from such hierarchically organized epithelial tissues retain features of cellular differentiation. Accumulating evidence suggests that the urothelium of the urinary
Antonina Kurtova, Keith Syson Chan
exaly   +3 more sources

Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem cells (MSCs), as adult multipotent cells, possess considerable regenerative and anti-neoplastic effects, from inducing apoptosis in the cancer cells to reducing multidrug resistance that bring them up as an appropriate alternative for ...
Kasra Moeinabadi-Bidgoli, Kasra Moeinabadi-Bidgoli, Malihe Rezaee, Malihe Rezaee, Hamidreza Rismanchi, Mohaddese Malek Mohammadi, Amirhesam Babajani   +6 more
doaj   +3 more sources

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation [PDF]

Nature, 2008
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour ...
LiQin Zhu, Paul Gibson, Yiai Tong
exaly   +3 more sources

Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis

Molecular Therapy: Oncolytics, 2020
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and secreted or membrane-bound interferon (IFN)-γ and tumor ...
Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong, Meng-Wei Ko   +10 more
doaj   +3 more sources