Results 11 to 20 of about 438,052 (300)

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation [PDF]

Nature, 2008
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour ...
Zhu, Liqin, Gibson, Paul, Currle, D. Spencer, Tong, Yiai, Richardson, Robert J., Bayazitov, Ildar T., Poppleton, Helen, Zakharenko, Stanislav, Ellison, David W., Gilbertson, Richard J.   +9 more
openaire   +4 more sources

Thrombopoietin in normal and neoplastic stem cell development [PDF]

Best Practice & Research Clinical Haematology, 2009
It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia
Kenneth, Kaushansky, Helen M, Ranney
openaire   +2 more sources

Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy

Cells, 2020
Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency of dystrophin that leads to skeletal muscle degeneration.
Aleksandra Klimczak, Agnieszka Zimna, Agnieszka Malcher, Urszula Kozlowska, Katarzyna Futoma, Jaroslaw Czarnota, Pawel Kemnitz, Anna Bryl, Maciej Kurpisz   +8 more
doaj   +1 more source

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +1 more source

Can supernatant from immortalized adipose tissue MSC replace cell therapy? An in vitro study in chronic wounds model

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing.
Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka, Aleksandra Klimczak   +9 more
doaj   +1 more source

STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT [PDF]

Gut, 2004
Stem cells are primitive cells located in a specialised mesenchymal “niche” that lack expression of any definitive markers of lineage commitment and are therefore difficult to define and identify. Stem cells maintain their capacity for limitless self replication throughout the lifetime of their host, and can also divide to produce daughter cells ...
M, Brittan, N A, Wright
openaire   +2 more sources

Microvesicles from Human Immortalized Cell Lines of Endothelial Progenitor Cells and Mesenchymal Stem/Stromal Cells of Adipose Tissue Origin as Carriers of Bioactive Factors Facilitating Angiogenesis

Stem Cells International, 2020
Endothelial progenitor cells (EPCs) and mesenchymal stem/stromal cells (MSCs) are associated with maintaining tissue homeostasis and tissue repair. Both types of cells contribute to tissue regeneration through the secretion of trophic factors (alone or ...
Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Honorata Kraskiewicz, Agnieszka Szyposzynska, Elżbieta Wojdat, Aleksandra Klimczak   +6 more
doaj   +1 more source

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

Brazilian Oral Research, 2021
The aim of this study was to identify tumor parenchyma cells exhibiting immunohistochemical profile of stem cells by evaluating the immunoreactivity of OCT4 and CD44 in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic
Jamile Marinho Bezerra de Oliveira Moura, Amanda Katarinny Goes Gonzaga, Salomão Israel Monteiro Lourenço Queiroz, Manoela Domingues Martins, Leão Pereira Pinto, Lélia Batista de Souza   +5 more
doaj   +1 more source

von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. [PDF]

PLoS Medicine, 2007
BACKGROUND: To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells from ...
Deric M Park, Zhengping Zhuang, Ling Chen, Nicholas Szerlip, Irina Maric, Jie Li, Taesung Sohn, Stephanie H Kim, Irina A Lubensky, Alexander O Vortmeyer, Griffin P Rodgers, Edward H Oldfield, Russell R Lonser   +12 more
doaj   +1 more source

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +7 more sources