Results 31 to 40 of about 387,984 (293)

Can supernatant from immortalized adipose tissue MSC replace cell therapy? An in vitro study in chronic wounds model

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing.
Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka, Aleksandra Klimczak   +9 more
doaj   +1 more source

Targeted transgenic RNAi knockdown of cell fate determinants induces neoplastic tumor growth and metastasis in a Drosophila transplantation model of neural stem cell derived cancer [PDF]

, 2012
Genetic models such as Drosophila have sophisticated transgenic and molecular genetic tools available to investigate proliferation control in normal and tumorigenic neural stem cells.
Reichert, Heinrich, Laurenson, Anne-Sophie, Saini, Nidhi, Jiang, Yanrui   +3 more
core   +1 more source

Tumor Microenvironment Role in Pancreatic Cancer Stem Cells

, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a majority of patients presenting with unresectable or metastatic disease, resulting in a poor 5-year survival rate.
Aaron Galindo-Vega, Vilma Maldonado-Lagunas, Irma B. Mitre-Aguilar, Jorge Melendez-Zajgla   +3 more
core   +1 more source

Combined TGF-β3 and FGF-2 Stimulation Enhances Chondrogenic Potential of Ovine Bone Marrow-Derived MSCs

Cells
Mesenchymal stem cells (MSCs) represent a promising cell source for cartilage tissue engineering due to their chondrogenic potential. However, current differentiation protocols result in limited efficiency.
Sandra Stamnitz, Agnieszka Krawczenko, Aleksandra Klimczak   +2 more
doaj   +1 more source

Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells

Oncotarget, 2015
Studies have implicated that a small sub-population of cells within a tumour, termed cancer stem cells (CSCs), have an enhanced capacity for tumour formation in multiple cancers and may be responsible for recurrence of the disease after treatment, including radiation.
Dingwall, Steve, Lee, Jung Bok, Guezguez, Borhane, Fiebig, Aline, McNicol, Jamie, Boreham, Douglas, Collins, Tony J., Bhatia, Mick   +7 more
openaire   +5 more sources

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon [PDF]

Cell Reports, 2014
Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages.
Baker, A.-M., Cereser, B., Melton, S., Fletcher, A.G., Rodriguez-Justo, M., Tadrous, P.J., Humphries, A., Elia, G., McDonald, S.A.C., Wright, N.A., Simons, B.D., Jansen, M., Graham, T.A.   +12 more
openaire   +9 more sources

Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro. [PDF]

, 2011
The success of Imatinib (IM) therapy in chronic myeloid leukemia (CML) is compromised by the development of IM resistance and by a limited IM effect on hematopoietic stem cells.
Carsten Bokemeyer, Balabanov, S., Moll, J., Tessa L. Holyoake, Edgar Jost, Braig, Melanie, Stefan Balabanov, Moll, Jürgen, Rohe, Imke, Gontarewicz, A., Gunhild Keller, von Amsberg, Gunhild, Braig, M., Holyoake, Tessa L., Jost, E., Rohe, I., Jost, Edgar, Bosotti, Roberta, Tim H Brümmendorf, Bosotti, R., Balabanov, Stefan, Barett, Christine, Artur Gontarewicz, Holyoake, T.L., Laura Raddrizzani, Brümmendorf, T.H., Gontarewicz, Artur, Roberta Bosotti, Barett, C., Raddrizzani, Laura, Melanie Braig, Raddrizzani, L., Bokemeyer, C., Jürgen Moll, Tessa L Holyoake, Keller, G., Tim H. Brümmendorf, Bokemeyer, Carsten, Brümmendorf, Tim Henrik, Imke Rohe, Christine Barett   +40 more
core   +1 more source

Surface Markers for the Identification of Cancer Stem Cells

, 2017
Cancer stem cells have genetic and functional characteristics that can turn them resistant to standard cancer therapeutic targets. Identification of these cells is challenging and is mostly done by detecting the expression of their antigens in a group of
Gopalan, Vinod, Lam, Alfred King-yin, Lam, Alfred, Farhadul Islam, Islam, Farhadul, Islam, Md. Farhadul, Vinod Gopalan, Alfred King-yin Lam   +7 more
core   +1 more source

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.

Frontiers in Physiology, 2013
Background: CD133 has been identified as a cancer stem cell (CSC) marker for pancreatic ductal adenocarcinoma. Although leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), a marker of intestinal stem cells, has been shown to be on a ...
Nobumasa eMizuno, Yasushi eYatabe, Kazuo eHara, Susumu eHijioka, Hiroshi eImaoka, Yasuhiro eShimizu, Shigeru B.H. Ko, Kenji eYamao   +7 more
doaj   +1 more source

A Murine Model With JAK2V617F Expression in Both Hematopoietic Cells and Vascular Endothelial Cells Recapitulates the Key Features of Human Myeloproliferative Neoplasm

Frontiers in Oncology, 2021
The myeloproliferative neoplasms (MPNs) are characterized by an expansion of the neoplastic hematopoietic stem/progenitor cells (HSPC) and an increased risk of cardiovascular complications.
Haotian Zhang, Amar Yeware, Sandy Lee, Huichun Zhan, Huichun Zhan   +4 more
doaj   +1 more source